Tamagawa Shunji, Okuda Katsuya, Nishikawa Daisuke, Kono Masamitsu, Hotomi Muneki
Department of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, JPN.
Department of Head and Neck Surgery, Aichi Cancer Center, Nagoya, JPN.
Cureus. 2024 Nov 29;16(11):e74742. doi: 10.7759/cureus.74742. eCollection 2024 Nov.
Near-infrared photoimmunotherapy (NIR-PIT) is a newly developed treatment. We report a successful case of NIR-PIT for post-irradiation locoregionally recurrent oropharyngeal cancer at the tongue base. A 60-year-old man following primary treatment for oropharyngeal cancer at the tongue base by endoscopy (rT1N0M0). He had been treated by concurrent chemoradiotherapy. NIR-PIT was performed under general anesthesia at the tongue base. Successful therapeutic effects were obtained with no postoperative functional impairment. This case report highlights two important management issues: tracheostomy and pain management after NIR-PIT. NIR-PIT for head and neck cancer will provide a curative treatment option for the locoregional recurrent or unresectable disease following radiotherapy and surgery. It was considered important to ensure sufficient optical tissue penetration range, control pain in the perioperative period, and take measures to prevent edema in the airway.
近红外光免疫疗法（NIR-PIT）是一种新开发的治疗方法。我们报告了一例成功使用NIR-PIT治疗舌根处放疗后局部区域复发性口咽癌的病例。一名60岁男性，曾接受内镜下舌根口咽癌的初始治疗（rT1N0M0）。他接受了同步放化疗。NIR-PIT在舌根处全身麻醉下进行。获得了成功的治疗效果，且术后无功能障碍。本病例报告突出了两个重要的管理问题：NIR-PIT后的气管切开术和疼痛管理。NIR-PIT用于治疗头颈癌将为放疗和手术后局部区域复发或不可切除的疾病提供一种治愈性治疗选择。确保足够的光学组织穿透范围、控制围手术期疼痛以及采取措施预防气道水肿被认为很重要。
