School of Agriculture, Ningxia University, Yinchuan 750021, China.
Key Laboratory of Ruminant Molecular Cell Breeding, Ningxia Hui Autonomous Region, Yinchuan 750021, China.
Cells. 2022 Nov 17;11(22):3642. doi: 10.3390/cells11223642.
Long noncoding RNAs (lncRNAs) are recently discovered genetic regulatory molecules that regulate immune responses and are closely associated with the occurrence and development of various diseases, including inflammation, in humans and animals. Under specific physiological conditions, lncRNA expression varies at the cell or tissue level, and lncRNAs can bind to specific miRNAs, target mRNAs, and target proteins to participate in certain processes, such as cell differentiation and inflammatory responses, via the corresponding signaling pathways. This review article summarizes the regulatory role of lncRNAs in macrophage polarization, dendritic cell differentiation, T cell differentiation, and endothelial and epithelial inflammation. In addition, it describes the molecular mechanism of lncRNAs in acute kidney injury, hepatitis, inflammatory injury of the lung, osteoarthritis, mastitis, and neuroinflammation to provide a reference for the molecular regulatory network as well as the genetic diagnosis and treatment of inflammatory diseases in humans and animals.
长链非编码 RNA（lncRNA）是最近发现的遗传调控分子，可调节免疫反应，与人类和动物的各种疾病（包括炎症）的发生和发展密切相关。在特定的生理条件下，lncRNA 在细胞或组织水平上的表达会发生变化，lncRNA 可以与特定的 miRNAs、靶 mRNAs 和靶蛋白结合，通过相应的信号通路参与细胞分化和炎症反应等特定过程。本文综述了 lncRNA 在巨噬细胞极化、树突状细胞分化、T 细胞分化以及内皮细胞和上皮细胞炎症中的调控作用。此外，还描述了 lncRNA 在急性肾损伤、肝炎、肺部炎症损伤、骨关节炎、乳腺炎和神经炎症中的分子机制，为炎症性疾病的分子调控网络以及人类和动物的遗传诊断和治疗提供参考。
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