División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa 86100, Mexico.
Laboratorio de Genómica de Enfermedades Psiquiátricas y Neurodegenerativas, Instituto Nacional de Medicina Genómica, Ciudad de Mexico 14610, Mexico.
Int J Environ Res Public Health. 2022 Nov 9;19(22):14735. doi: 10.3390/ijerph192214735.
Suicide attempts are an emerging health problem around the world. Increased levels of IL-6 have been associated with suicidal behavior. Therefore, the aims of this study were to evaluate the serum levels of IL-6 in individuals with suicide attempts and a comparison group and to associate the IL-6 levels with the lethality of the suicide attempt. Additionally, we associated the rs2228145 polymorphism of the gene with suicide attempts or with the IL-6 serum levels. Suicide attempts and their lethality were evaluated using the Columbia Suicide Severity Rating Scale. The serum concentrations of IL-6 were measured by the ELISA technique in individuals with suicide attempts and then compared to a control group. The rs2228145 polymorphism of the gene was analyzed by real-time polymerase chain reaction. We found elevated serum levels of IL-6 in the suicide attempt group when compared to the control group (F = 10.37, = 0.002). However, we found no differences of the IL-6 levels between high and low lethality. The gene polymorphism rs2479409 was not associated with suicide attempts. Our data suggest that IL-6 serum is increased in individuals with suicide attempts.
自杀企图是全世界日益严重的健康问题。白细胞介素 6（IL-6）水平升高与自杀行为有关。因此，本研究旨在评估自杀未遂者和对照组的血清 IL-6 水平，并将 IL-6 水平与自杀未遂的致命性相关联。此外，我们还将基因的 rs2228145 多态性与自杀企图或血清 IL-6 水平相关联。自杀企图及其致命性采用哥伦比亚自杀严重程度评定量表进行评估。通过酶联免疫吸附试验（ELISA）技术测量自杀未遂者的血清 IL-6 浓度，然后与对照组进行比较。通过实时聚合酶链反应（PCR）分析基因的 rs2228145 多态性。与对照组相比，自杀未遂组的血清 IL-6 水平升高（F = 10.37，p = 0.002）。然而，我们发现高致命性和低致命性之间的 IL-6 水平没有差异。基因多态性 rs2479409 与自杀企图无关。我们的数据表明，自杀未遂者的血清 IL-6 水平升高。
