Seeburg P H, Shine J, Martial J A, Ivarie R D, Morris J A, Ullrich A, Baxter J D, Goodman H M
Nature. 1978;276(5690):795-8. doi: 10.1038/276795a0.
A hybrid gene was constructed between the beta-lactamase gene of plasmid pBR322 and the cloned coding sequence for rat growth hormone. This gene is expressed in bacteria and growth hormone sequences are detectable by immunological methods.
在质粒pBR322的β-内酰胺酶基因与克隆的大鼠生长激素编码序列之间构建了一个杂种基因。该基因在细菌中表达,并且可用免疫学方法检测到生长激素序列。