Department of Analytical Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, 10000 Zagreb, Croatia.
Pliva Croatia TAPI R&D, 10000 Zagreb, Croatia.
Molecules. 2022 Nov 18;27(22):8008. doi: 10.3390/molecules27228008.
Pharmaceuticals are known for their great effects and applications in the treatment and suppression of various diseases in human and veterinary medicine. The development and modernization of science and technologies have led to a constant increase in the production and consumption of various classes of pharmaceuticals, so they pose a threat to the environment, which can be subjected to the sorption process on the solid phase. The efficiency of sorption is determined by various parameters, of which the physicochemical properties of the compound and the sorbent are very important. One of these parameters that determine pharmaceutical mobility in soil or sediment is the soil−water partition coefficient normalized to organic carbon (Koc), whose determination was the purpose of this study. The influence of organic matter, suspended in an aqueous solution of pharmaceutical (more precisely: cefdinir, memantine, and praziquantel), was studied for five different types of soil and sediment samples from Croatia. The linear, Freundlich, and Dubinin−Raduskevich sorption isotherms were used to determine specific constants such as the partition coefficient Kd, which directly describes the strength of sorbate and sorbent binding. The linear model proved to be the best with the highest correlation coefficients, R2 > 0.99. For all three pharmaceuticals, a positive correlation between sorption affinity described by Kd and Koc and the amount of organic matter was demonstrated.
药品以其在人类和兽医医学中治疗和抑制各种疾病的巨大效果和应用而闻名。科学技术的发展和现代化导致了各种类别的药品的生产和消费不断增加，因此它们对环境构成了威胁，环境可能会受到固相吸附过程的影响。吸附的效率取决于各种参数，其中化合物和吸附剂的物理化学性质非常重要。决定药品在土壤或沉积物中迁移性的这些参数之一是归一化到有机碳的土壤-水分配系数（Koc），本研究的目的就是确定这一系数。本研究考察了在水溶液中悬浮有有机物（更确切地说：头孢地尼、美金刚和吡喹酮）时，五种不同类型的克罗地亚土壤和沉积物样品对药品的影响。线性、弗伦德利希和杜宾宁-拉道斯基吸附等温线用于确定特定常数，如分配系数 Kd，它直接描述了吸附质和吸附剂的结合强度。线性模型被证明是最好的，相关系数 R2>0.99 很高。对于所有三种药品，都证明了由 Kd 和 Koc 描述的吸附亲和力与有机物含量之间存在正相关关系。
