Department of Analytical Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, 10000, Zagreb, Croatia.
Pliva Croatia TAPI R&D, Zagreb, Croatia.
Environ Sci Pollut Res Int. 2022 Sep;29(44):66841-66857. doi: 10.1007/s11356-022-20398-5. Epub 2022 May 5.
The everyday use of various pharmaceuticals to treat humans or animals means that they are increasingly found in the environment. Contamination of the soil can cause the active ingredients to be strongly sorbed to the soil or sediment. In the worst case, they can also be expected to occur in the aquatic environment due to their different polarity. In this study, four drugs from different therapeutic classes (trimetoprim, memantine, cefdinir, praziquantel) were used in dissolved form in two sediment and three soil samples to obtain data that can describe their fate and behavior in the environment. The sorption affinities of the pharmaceuticals were described using linear, Freundlich and Dubinin-Radushkevich sorption isotherms. The highest K values were obtained for cefdinir, while memantine and praziquantel tended to be present in water due to their very low sorption coefficients. The studied influence of pH showed a negative trend for memantine and trimetoprim, while an increase in ionic strength resulted in higher K values for all drugs. The sorption mechanism for all tested samples was best described by the pseudo-secondary kinetic model (R > 0.9999).
各种用于治疗人类或动物的药物在日常生活中的广泛使用意味着它们越来越多地出现在环境中。土壤的污染会导致有效成分强烈地被土壤或沉积物吸附。在最坏的情况下，由于它们不同的极性，也可以预期它们会出现在水生环境中。在这项研究中，四种来自不同治疗类别的药物（甲氧苄啶、美金刚、头孢地尼、吡喹酮）以溶解形式用于两种沉积物和三种土壤样品中，以获得能够描述它们在环境中的命运和行为的数据。使用线性、弗伦德利希和杜宾-拉什科夫斯基吸附等温线描述了药物的吸附亲和力。头孢地尼的 K 值最高，而由于美金刚和吡喹酮的吸附系数非常低，它们往往存在于水中。所研究的 pH 影响对美金刚和甲氧苄啶呈负趋势，而离子强度的增加导致所有药物的 K 值升高。对于所有测试的样品，吸附机制都可以通过拟二级动力学模型（R > 0.9999）得到最好的描述。
