Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.
Division of Obstetrics and Gynecology, Department of Perinatology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.
Sensors (Basel). 2022 Nov 21;22(22):8994. doi: 10.3390/s22228994.
Electrohysterography has been used for monitoring uterine contractility in pregnancy and labour. Effective uterine contractility is crucial for preventing postpartum haemorrhage. The objective of our study was to compare postpartum electrohysterograms in women receiving oxytocin vs. carbetocin for postpartum haemorrhage prevention after caesarean delivery. The trial is registered at ClinicalTrials.gov with the identifier NCT04201665. We included 64 healthy women with uncomplicated singleton pregnancies at term scheduled for caesarean section after one previous caesarean section. After surgery, a 15 min electrohysterogram was obtained after which women were randomised to receive either five IU of oxytocin intravenously or 100 μg of carbetocin intramuscularly. A 30 min electrohysterogram was performed two hours after drug application. Changes in power density spectrum peak frequency of electrohysterogram pseudo-bursts were analysed. A significant reduction in power density spectrum peak frequency in the first two hours was observed after carbetocin but not after oxytocin (median = 0.07 (interquartile range (IQR): 0.87 Hz) compared to median = -0.63 (IQR: 0.20) Hz; = 0.004). Electrohysterography can be used for objective comparison of uterotonic effects. We found significantly higher power density spectrum peak frequency two hours after oxytocin compared to carbetocin.
电子宫描记术已用于妊娠和分娩期间监测子宫收缩力。有效的子宫收缩力对于预防产后出血至关重要。我们的研究目的是比较接受催产素与卡贝缩宫素预防剖宫产产后出血的女性产后电子宫描记图。该试验在 ClinicalTrials.gov 注册，标识符为 NCT04201665。我们纳入了 64 名健康的、经产妇、单胎妊娠足月、既往有一次剖宫产史的女性，行择期剖宫产。手术后，获得 15 分钟的电子宫描记图，然后将女性随机分为静脉注射 5IU 催产素或肌肉注射 100μg 卡贝缩宫素。在药物应用后 2 小时进行 30 分钟的电子宫描记图。分析电子宫描记图伪爆发的功率谱峰值频率的变化。卡贝缩宫素后前两小时的功率谱峰值频率明显降低，但催产素后则没有（中位数=0.07（四分位距（IQR）：0.87Hz）与中位数=-0.63（IQR：0.20）Hz；=0.004）。电子宫描记术可用于比较子宫收缩药物的客观效果。我们发现催产素后两小时的功率谱峰值频率明显高于卡贝缩宫素。
