Department of Obstetrics, the First Affiliated Hospital of Chongqing Medical University, No. 1, Youyilu Street, Yuzhong District, 400016, Chongqing, China.
Department of Oncology, Chongqing University Cancer Hospital, 400030, Chongqing, China.
BMC Pregnancy Childbirth. 2022 Nov 26;22(1):877. doi: 10.1186/s12884-022-05203-y.
Pregnant women expecting twins are more likely to experience stress, which can lead to anxiety and depression. Our aim was to investigate the prevalence of prenatal anxiety and depressive symptoms in women with twin pregnancies and the associated factors.
In a cross-sectional survey, 210 women with twin pregnancies who satisfied the inclusion and exclusion criteria in two tertiary centers in Southwestern China were asked to complete a basic information form, the Self-Rating Anxiety Scale (SAS) and the Self-Rating Depression Scale (SDS). To compare statistics with normal distribution in distinct characteristic groups, a paired t-test, and one-way ANOVA were utilized. Binary logistic step regression was used to analyze the associated factors of antenatal anxiety and depressive symptoms.
The 210 women with twin pregnancies (age = 30.8 ± 4.2 years) were between 7 and 37 gestational weeks (29.2 ± 1.2 weeks), were typically well-educated (72.4% had a post-high-school degree), and reasonably affluent (88.1% were above the low-income cutoff). Among them, 34.8% had symptoms associated with clinical levels of anxiety, and 37.1% had symptoms indicating possible depression. The prevalence of co-morbid anxiety and depressive symptoms was 24.3%. Binary stepwise logistic regression analysis showed that previous health status and sleep disturbance during pregnancy were the associated factors of anxiety symptoms in women with twin pregnancies (P < 0.05), whereas age, previous health status, negative life events, and physical activity during pregnancy were the associated factors of depressive symptoms in women with twin pregnancies (P < 0.05).
About one-third of women with twin pregnancies had symptoms of anxiety or depression; these were most strongly predicted by some modifiable factors, suggesting that early preventive mind-body interventions may be a promising strategy to protect against mental health issues for women with twin pregnancies.
怀双胞胎的孕妇更有可能感到压力，这可能导致焦虑和抑郁。我们的目的是调查中国西南部两家三级中心的双胞胎孕妇产前焦虑和抑郁症状的发生率及相关因素。
采用横断面调查方法，对符合纳入和排除标准的 210 名双胞胎孕妇进行基本信息表、焦虑自评量表（SAS）和抑郁自评量表（SDS）调查。对于具有不同特征组的统计学比较，采用配对 t 检验和单因素方差分析。采用二元 Logistic 逐步回归分析产前焦虑和抑郁症状的相关因素。
210 名双胞胎孕妇（年龄 30.8±4.2 岁）的孕周为 7 至 37 周（29.2±1.2 周），受教育程度较高（72.4%为高中以上学历），收入水平较高（88.1%高于低收入标准）。其中，34.8%的孕妇出现与临床水平相关的焦虑症状，37.1%的孕妇出现可能的抑郁症状。同时患有焦虑和抑郁症状的孕妇占 24.3%。二元逐步 Logistic 回归分析显示，既往健康状况和孕期睡眠障碍是双胞胎孕妇焦虑症状的相关因素（P<0.05），而年龄、既往健康状况、负性生活事件和孕期体力活动是双胞胎孕妇抑郁症状的相关因素（P<0.05）。
约三分之一的双胞胎孕妇出现焦虑或抑郁症状；这些症状主要受一些可改变的因素预测，提示对双胞胎孕妇进行早期预防性身心干预可能是保护其心理健康的一种有前景的策略。
