Tel Aviv Sourasky Medical Center, Tel Aviv University, Sackler School of Medicine, Tel Aviv, Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Tel Aviv Sourasky Medical Center, Tel Aviv University, Sackler School of Medicine, Tel Aviv, Israel, Internal Medicine B, Sheba Medical Center, Tel Hashomer, Israel.
Isr Med Assoc J. 2022 Nov;24(11):737-740.
Fibromyalgia syndrome (FMS) is characterized by widespread musculoskeletal pain and tenderness with associated neuropsychological symptoms such as fatigue, unrefreshing sleep, cognitive dysfunction, anxiety, and depression. Osteoporosis is defined as a reduction of bone density. Previous studies to determine an association of FMS with osteoporosis showed mixed results, partially due to small sample sizes and lack of statistical power.
To evaluate the association of FMS with osteoporosis.
We conducted a case-control study utilizing the database from Israel's largest health maintenance organization. FMS patients were compared to age- and sex-matched controls. Data were analyzed using chi-square and t-tests. Multivariable logistic regression models assessed the association between osteoporosis and FMS. Spearman's rho test was used for correlation.
We utilized data from 14,296 FMS patients and 71,324 age- and sex-matched controls. Spearman's rho test showed a significant correlation between FMS and osteoporosis (correlation coefficient 0.55, P < 0.001). A logistic regression for osteoporosis showed an odds ratio [OR] of 1.94 (95% confidence interval [95%CI] 1.83-2.06, P < 0.001) for FMS compared to controls and found higher body mass index to be slight protective (OR 0.926, 95%CI 0.92-0.93, P < 0.001).
There is a significant correlation between FMS and osteoporosis. Early detection of predisposing factors for osteoporosis in FMS patients and implementation of suitable treatments and prevention measures (such as dietary supplements, resistance or weight bearing exercise, and bone-mineral enhancing pharmacological therapy) may reduce both occurrence rate and severity of osteoporosis and its complications, such as fractures.
纤维肌痛综合征（FMS）的特征是广泛的肌肉骨骼疼痛和压痛，并伴有神经心理症状，如疲劳、睡眠不足、认知功能障碍、焦虑和抑郁。骨质疏松症定义为骨密度降低。以前的研究表明，FMS 与骨质疏松症之间存在关联，但结果不一，部分原因是样本量小且缺乏统计学效力。
评估 FMS 与骨质疏松症之间的关联。
我们利用以色列最大的健康维护组织的数据库进行了病例对照研究。将 FMS 患者与年龄和性别匹配的对照组进行比较。使用卡方检验和 t 检验进行数据分析。多变量逻辑回归模型评估了骨质疏松症与 FMS 之间的关联。使用斯皮尔曼 rho 检验进行相关性分析。
我们利用了来自 14296 名 FMS 患者和 71324 名年龄和性别匹配的对照组的数据。斯皮尔曼 rho 检验显示 FMS 与骨质疏松症之间存在显著相关性（相关系数 0.55，P < 0.001）。骨质疏松症的逻辑回归显示，与对照组相比，FMS 的优势比（OR）为 1.94（95%置信区间[95%CI]为 1.83-2.06，P < 0.001），而较高的体重指数则略有保护作用（OR 0.926，95%CI 0.92-0.93，P < 0.001）。
FMS 与骨质疏松症之间存在显著相关性。早期发现 FMS 患者骨质疏松症的易患因素，并实施适当的治疗和预防措施（如膳食补充剂、抗阻或负重运动以及增强骨矿物质的药物治疗），可能会降低骨质疏松症及其并发症（如骨折）的发生率和严重程度。
