Platform of Clinical Investigation Department, Inserm CIC 1405, University Hospital Clermont-Ferrand, F-63000 Clermont-Ferrand, France.
Inserm 1107, Neuro-Dol, University Clermont Auvergne, F-63000 Clermont-Ferrand, France.
Int J Mol Sci. 2023 Aug 31;24(17):13513. doi: 10.3390/ijms241713513.
A significant clinical association between osteoporosis (OP) and fibromyalgia (FM) has been shown in the literature. Given the need for specific biomarkers to improve OP and FM management, common miRNAs might provide promising tracks for future prevention and treatment. The aim of this review is to identify miRNAs described in OP and FM, and dysregulated in the same direction in both pathologies. The PubMed database was searched until June 2023, with a clear mention of OP, FM, and miRNA expression. Clinical trials, case-control, and cross-sectional studies were included. Gray literature was not searched. Out of the 184 miRNAs found in our research, 23 are shared by OP and FM: 7 common miRNAs are dysregulated in the same direction for both pathologies (3 up-, 4 downregulated). The majority of these common miRNAs are involved in the Wnt pathway and the cholinergic system and a possible link has been highlighted. Further studies are needed to explore this relationship. Moreover, the harmonization of technical methods is necessary to confirm miRNAs shared between OP and FM.
骨质疏松症 (OP) 和纤维肌痛 (FM) 之间存在显著的临床关联，这在文献中已有显示。鉴于需要特定的生物标志物来改善 OP 和 FM 的管理，常见的 miRNAs 可能为未来的预防和治疗提供有希望的途径。本综述的目的是确定在 OP 和 FM 中描述的 miRNAs，并确定在两种病理中以相同方向失调的 miRNAs。检索了 PubMed 数据库，截至 2023 年 6 月，明确提到了 OP、FM 和 miRNA 表达。纳入了临床试验、病例对照和横断面研究。未检索灰色文献。在我们的研究中发现的 184 个 miRNAs 中，有 23 个在 OP 和 FM 中共有：有 7 个常见的 miRNAs 在两种病理中以相同方向失调（3 个上调，4 个下调）。这些常见的 miRNAs 大多与 Wnt 途径和胆碱能系统有关，并强调了它们之间可能存在联系。需要进一步的研究来探索这种关系。此外，有必要协调技术方法以确认 OP 和 FM 之间共享的 miRNAs。
