Department of Neurosurgery, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15, Kuramoto-cho, Tokushima, 770-8503, Japan.
Department of Advanced Brain Research, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, 770-8503, Japan.
Sci Rep. 2022 Nov 27;12(1):20350. doi: 10.1038/s41598-022-24826-x.
We aimed to clarify the correlations between motor symptoms and obsessive-compulsive symptoms and between the volumes of basal ganglia components and obsessive-compulsive symptoms. We retrospectively included 14 patients with medically intractable, moderate and severe generalized dystonia. The Burke-Fahn-Marsden Dystonia Rating Scale and Maudsley Obsessional Compulsive Inventory were used to evaluate the severity of dystonia and obsessive-compulsive symptoms, respectively. Patients with generalized dystonia were divided into two groups; patients whose Maudsley Obsessional Compulsive Inventory score was lower than 13 (Group 1) and 13 or more (Group 2). Additionally, the total Maudsley Obsessional Compulsive Inventory scores in patients with dystonia were significantly higher than normal volunteers' scores (p = 0.025). Unexpectedly, Group 2 (high Maudsley Obsessional Compulsive Inventory scores) showed milder motor symptoms than Group 1 (low Maudsley Obsessional Compulsive Inventory scores) (p = 0.016). "Checking" rituals had a strong and significant negative correlation with the Burke-Fahn-Marsden Dystonia Rating Scale (ρ = - 0.71, p = 0.024) and a strong positive correlation with the volumes of both sides of the nucleus accumbens (right: ρ = 0.72, p = 0.023; left: ρ = 0.70, p = 0.034). Our results may provide insights into the pathogenesis of obsessive-compulsive disorder and dystonia.
我们旨在阐明运动症状与强迫症状之间的相关性，以及基底神经节成分体积与强迫症状之间的相关性。我们回顾性纳入了 14 名患有医学上难治性、中度和重度全身性肌张力障碍的患者。使用 Burke-Fahn-Marsden 肌张力障碍评定量表和 Maudsley 强迫性量表分别评估肌张力障碍和强迫症状的严重程度。将全身性肌张力障碍患者分为两组：Maudsley 强迫性量表得分低于 13 分的患者（组 1）和 13 分或以上的患者（组 2）。此外，肌张力障碍患者的总 Maudsley 强迫性量表评分明显高于正常志愿者的评分（p=0.025）。出乎意料的是，Maudsley 强迫性量表得分较高的组 2（Group 2）的运动症状比 Maudsley 强迫性量表得分较低的组 1（Group 1）更轻（p=0.016）。“检查”仪式与 Burke-Fahn-Marsden 肌张力障碍评定量表呈强烈负相关（ρ=-0.71，p=0.024），与双侧伏隔核的体积呈强烈正相关（右侧：ρ=0.72，p=0.023；左侧：ρ=0.70，p=0.034）。我们的结果可能为强迫症和肌张力障碍的发病机制提供新的见解。
