Tan Zhi-Xiang, Tao Rui, Li Si-Cheng, Shen Bing-Zheng, Meng Lan-Xia, Zhu Zhan-Yong
Department of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China.
Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China.
World J Diabetes. 2022 Nov 15;13(11):962-971. doi: 10.4239/wjd.v13.i11.962.
The adverse consequences resulting from diabetes are often presented as severe complications. Diabetic wounds are one of the most commonly occurring complications in diabetes, and the control and treatment of this is costly. Due to a series of pathophysiological mechanisms, diabetic wounds remain in the inflammatory phase for a prolonged period of time, and face difficulty in entering the proliferative phase, thus leading to chronic non-healing wounds. The current consensus on the treatment of diabetic wounds is through multidisciplinary comprehensive management, however, standard wound treatment methods are still limited and therefore, more effective methods are required. In recent years, defensins have been found to play diverse roles in a variety of diseases; however, the molecular mechanisms underlying these activities are still largely unknown. Defensins can be constitutively or inductively produced in the skin, therefore, their local distribution is affected by the microenvironment of these diabetic wounds. Current evidence suggests that defensins are involved in the diabetic wound pathogenesis, and can potentially promote the early completion of each stage, thus making research on defensins a promising area for developing novel treatments for diabetic wounds. In this review, we describe the complex function of human defensins in the development of diabetic wounds, and suggest potential thera-peutic benefits.
糖尿病所导致的不良后果通常表现为严重并发症。糖尿病伤口是糖尿病最常见的并发症之一，其控制和治疗成本高昂。由于一系列病理生理机制，糖尿病伤口在炎症期持续时间较长，进入增殖期困难，从而导致慢性不愈合伤口。目前关于糖尿病伤口治疗的共识是通过多学科综合管理，然而，标准的伤口治疗方法仍然有限，因此需要更有效的方法。近年来，已发现防御素在多种疾病中发挥多种作用；然而，这些活性背后的分子机制仍大多未知。防御素可在皮肤中组成性或诱导性产生，因此，它们的局部分布受这些糖尿病伤口微环境的影响。现有证据表明，防御素参与糖尿病伤口发病机制，并有可能促进各阶段的早期完成，因此对防御素的研究是开发糖尿病伤口新疗法的一个有前景的领域。在本综述中，我们描述了人类防御素在糖尿病伤口发展中的复杂功能，并提出了潜在的治疗益处。
