Vice President's Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, 63225, Langen, Germany.
Curr Allergy Asthma Rep. 2023 Jan;23(1):29-40. doi: 10.1007/s11882-022-01057-8. Epub 2022 Nov 28.
Recent high-level publications have shown an intricate connection between immune effector function and the metabolic state of the respective cells. In the last years, studies have begun analyzing the metabolic changes associated with allergies. As the first part of a two-article series, this review will briefly summarize the basics of immune metabolism and then focus on the recently published studies on metabolic changes observed in allergic patients.
In the last 3 years, immune-metabolic research in allergology had a clear focus on asthma with some studies also reporting findings in food allergy and atopic dermatitis. Current results suggest asthma to be associated with a shift in cellular metabolism towards increased aerobic glycolysis (Warburg metabolism), while also displaying substantial changes in fatty acid- and amino acid metabolism (depending on investigated patient collective, asthma phenotype, and disease severity). Understanding immune-metabolic changes in allergies will allow us to (I) better understand allergic disease pathology and (II) modulate immune-metabolic pathways to improve allergy treatment.
最近的高水平出版物表明，免疫效应功能与相应细胞的代谢状态之间存在复杂的联系。在过去的几年中，研究开始分析与过敏相关的代谢变化。作为两篇系列文章的第一部分，本综述将简要总结免疫代谢的基础知识，然后重点介绍最近发表的关于过敏患者观察到的代谢变化的研究。
在过去的 3 年中，过敏领域的免疫代谢研究主要集中在哮喘上，一些研究也报告了食物过敏和特应性皮炎的发现。目前的结果表明，哮喘与细胞代谢向有氧糖酵解（Warburg 代谢）的转变有关，同时在脂肪酸和氨基酸代谢方面也发生了显著变化（取决于所研究的患者群体、哮喘表型和疾病严重程度）。了解过敏中的免疫代谢变化将使我们能够（I）更好地了解过敏疾病的病理学，和（II）调节免疫代谢途径以改善过敏治疗。
