Department of Pharmacy Practice, Amrita School of Pharmacy, AIMS Health Science Campus, Amrita Vishwa Vidyapeetham, Kochi, Kerala, 682041, India.
Department of Basic Medical Sciences, College of Applied Medical Sciences, King Khalid University, Khamis Mushayt, Kingdom of Saudi Arabia.
Arch Pharm Res. 2022 Dec;45(12):849-864. doi: 10.1007/s12272-022-01417-y. Epub 2022 Nov 28.
Phytoestrogens are non-steroidal, polyphenolic compounds that are derived from plants and have biological properties similar to those of human estrogens. Their bioactivity, which is based on the core ring system, is caused by their structural resemblance to estrogen. Flavonoids, coumestans, lignans, and stilbenes are the four major categories into which they can be divided. They are structurally and functionally related to ovarian and placental estrogens, which are essential in female reproductive processes. Phytoestrogens are present in numerous dietary supplements and find application in hormone replacement therapy as an alternative to synthetic hormones. In addition, they provide health benefits for osteoporosis, heart disease, breast cancer, and prostate cancer. There is a growing interest in using phytoestrogen as preventative medicine in the form of nutraceuticals. This literature provides comprehensive information about the types, sources, and biological actions of phytoestrogens in the reproductive system.
植物雌激素是一类非甾体、多酚类化合物,来源于植物,具有类似人体雌激素的生物学特性。它们的生物活性基于核心环系统,其结构与雌激素相似,导致其具有雌激素活性。黄酮类、香豆素类、木脂素类和芪类是其主要的四大类别。它们在结构和功能上与卵巢和胎盘雌激素相关,后者在女性生殖过程中至关重要。植物雌激素存在于许多膳食补充剂中,并作为合成激素的替代品应用于激素替代疗法。此外,它们对骨质疏松症、心脏病、乳腺癌和前列腺癌具有健康益处。人们越来越感兴趣地将植物雌激素作为预防性药物,以营养保健品的形式使用。本文献提供了关于植物雌激素在生殖系统中的类型、来源和生物学作用的全面信息。