利用相对定量检测比较中国的 Lagovirus europaeus GI.1 和 GI.2 株的致病性。
The pathogenicity comparison of Lagovirus europaeus GI.1 and GI.2 strains in China by using relative quantitative assay.
机构信息
Key Laboratory of Animal Diseases and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China.
Branch of Animal Husbandry and Veterinary Medicine, Chengdu Agricultural College, Chengdu, 611130, China.
出版信息
Sci Rep. 2022 Nov 28;12(1):20518. doi: 10.1038/s41598-022-25118-0.
Lagovirus europaeus GI.1 belongs to Lagovirus in the Caliciviridae family. GI.1 causes an acute, septic, and highly lethal disease in rabbits. Lagovirus europaeus GI.2, a new variant of GI.1, has caused explosive mortality in rabbits of all ages in Sichuan Province, China. To explore the differences in pathogenicity of rabbits infected with GI.1/GI.2, we investigated the virulence and disease progression of a naturally occurring GI.1/GI.2 in 4-week-old, 13-week-old, and 25-week-old New Zealand White laboratory rabbits after GI.1/GI.2 infection. Objective measures of disease progression were recorded using continuous body-temperature monitoring. We observed the kittens were infected with GI.2 during the most urgent course of the disease, and GI.1 was not lethal to kittens. We found that the target organ of both GI.1 and GI.2 was the liver, but the disease course of the two viruses was differed. Our study enriches the research on the pathogenicity of GI.1 and GI.2 under the same conditions.
欧洲兔轮状病毒 GI.1 属于杯状病毒科轮状病毒属。GI.1 可引起家兔急性、败血性和高致死性疾病。欧洲兔轮状病毒 GI.2 是 GI.1 的一个新变体，在中国四川省已导致各年龄段家兔的爆发性死亡。为了探讨感染 GI.1/GI.2 的兔子在致病性方面的差异，我们研究了自然发生的 GI.1/GI.2 在 4 周龄、13 周龄和 25 周龄新西兰白兔感染后的毒力和疾病进展情况。通过连续体温监测记录疾病进展的客观指标。我们观察到幼猫在疾病最危急的过程中感染了 GI.2，而 GI.1 对幼猫没有致命性。我们发现，GI.1 和 GI.2 的靶器官都是肝脏，但这两种病毒的疾病过程不同。我们的研究丰富了在相同条件下对 GI.1 和 GI.2 致病性的研究。
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