Chadani Yoshihiro, Kashibayashi Tetsuo, Yamamoto Takahiro, Tsuda Atsushi, Fujito Ryoko, Akamatsu Masanori, Kamimura Naoto, Takahashi Ryuichi, Yamagami Takuji, Furuya Hirokazu, Ueba Tetsuya, Saito Motoaki, Inoue Keiji, Kazui Hiroaki
Department of Neuropsychiatry, Kochi Medical School, Kochi University, Kohasu Oko-Cho, Nankoku, Kochi, 783-8505, Japan.
Department of Psychiatry, Hyogo Prefectural Harima-Himeji General Medical Center, Himeji, Hyogo, Japan.
Sci Rep. 2022 Nov 28;12(1):20428. doi: 10.1038/s41598-022-23800-x.
Apathy is frequently observed in idiopathic normal pressure hydrocephalus (iNPH) and worsens cognitive impairment and gait disturbance. In this study, we evaluated the regions associated with apathy in iNPH using statistical imaging analysis on the whole brain, both in terms of cerebral blood flow and gray matter volume. Twenty-seven patients with iNPH were assigned to two groups based on their scores on the neuropsychiatric inventory items related to apathy; 18 patients were assigned to the group with apathy (iNPH + APA) and 9 to the group without apathy (iNPH - APA). The magnetic resonance images and cerebral blood flow single-photon emission computed tomography data of the two groups were compared using statistical parametric mapping 12. The regional gray matter volume of the right precuneus was significantly larger in the iNPH + APA group than in the iNPH - APA group, but the regional cerebral blood flow in any region of the brain was not significantly different between the two groups. These results suggested that the larger gray matter volume, which is thought to reflect gray matter compression, in the precuneus might be involved in apathy in iNPH.
冷漠在特发性正常压力脑积水（iNPH）中经常出现，并且会加重认知障碍和步态紊乱。在本研究中，我们使用全脑统计成像分析，从脑血流量和灰质体积两方面评估了iNPH中与冷漠相关的区域。27例iNPH患者根据其在与冷漠相关的神经精神量表项目上的得分被分为两组；18例患者被分配到有冷漠症状的组（iNPH + APA），9例被分配到无冷漠症状的组（iNPH - APA）。使用统计参数映射12比较了两组的磁共振图像和脑血流量单光子发射计算机断层扫描数据。iNPH + APA组右侧楔前叶的区域灰质体积显著大于iNPH - APA组，但两组之间大脑任何区域的区域脑血流量均无显著差异。这些结果表明，楔前叶中较大的灰质体积（被认为反映灰质压缩）可能与iNPH中的冷漠有关。
