Department of Emergency Medicine, College of Medicine, Chung-Ang University, Seoul, Korea.
Yonsei Med J. 2022 Dec;63(12):1121-1129. doi: 10.3349/ymj.2022.0339.
To evaluate the effect of coronavirus disease 2019 (COVID-19) on out-of-hospital cardiac arrest (OHCA) outcomes in South Korea, we conducted systematic review and meta-analysis.
MEDLINE, Embase, KoreaMed, and Korean Information Service System databases were searched up to June 2022. We included observational studies and letters on OHCA during the COVID-19 pandemic and compared them to those before the pandemic. Epidemiologic characteristics, including at-home OHCA, bystander cardiopulmonary resuscitation, unwitnessed arrest, use of an automated external defibrillator (AED), shockable cardiac rhythm, and airway management, were evaluated. Survival and favorable neurological outcomes were extracted. We conducted a meta-analysis of each characteristic and outcome.
Six studies including 4628 OHCA patients were included in this study. The incidence of at-home OHCA significantly increased and the AED use decreased during the COVID-19 pandemic compared to before the pandemic [odds ratio (OR), 1.29; 95% confidence interval (CI), 1.08-1.55; I²=0% and OR, 0.74; 95% CI, 0.57-0.97; I²=0%, respectively]. Return of spontaneous circulation after OHCA, survival, and favorable neurological outcomes during and before the pandemic did not differ significantly (OR, 0.90; 95% CI, 0.71-1.13; I²=37%; OR, 0.74; 95% CI, 0.43-1.26; I²=72%; OR, 0.77; 95% CI, 0.43-1.37; I²=70%, respectively).
During the COVID-19 pandemic in South Korea, the incidence of at-home OHCA increased and AED use decreased among OHCA patients. However, survival and favorable neurological outcomes did not significantly differ from before the pandemic. This insignificant effect of the pandemic on OHCA in South Korea could be attributed to the slow increase in patient count in the early days of the pandemic. OSF Registry (DOI: 10.17605/OSF.IO/UGE9D).
评估 2019 年冠状病毒病（COVID-19）对韩国院外心脏骤停（OHCA）结局的影响，我们进行了系统评价和荟萃分析。
检索了 MEDLINE、Embase、KoreaMed 和韩国信息服务系统数据库，检索时间截至 2022 年 6 月。我们纳入了 COVID-19 大流行期间和之前的 OHCA 的观察性研究和信函，并将其进行了比较。评估了流行病学特征，包括在家中发生的 OHCA、旁观者心肺复苏、无人见证的骤停、使用自动体外除颤器（AED）、可电击性心脏节律和气道管理。提取了生存率和良好的神经功能结局。我们对每个特征和结局进行了荟萃分析。
本研究纳入了 6 项研究共 4628 例 OHCA 患者。与大流行前相比，COVID-19 大流行期间在家中发生 OHCA 的发生率显著增加，AED 使用减少[比值比（OR），1.29；95%置信区间（CI），1.08-1.55；I²=0%和 OR，0.74；95%CI，0.57-0.97；I²=0%]。OHCA 后自主循环恢复、生存和大流行期间和之前的良好神经功能结局无显著差异（OR，0.90；95%CI，0.71-1.13；I²=37%；OR，0.74；95%CI，0.43-1.26；I²=72%；OR，0.77；95%CI，0.43-1.37；I²=70%）。
在韩国 COVID-19 大流行期间，OHCA 患者在家中发生 OHCA 的发生率增加，AED 使用减少。然而，生存率和良好的神经功能结局与大流行前无显著差异。COVID-19 对韩国 OHCA 影响不显著可能归因于大流行早期患者数量缓慢增加。OSF 注册（DOI：10.17605/OSF.IO/UGE9D）。
