Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok 10400, Thailand.
Department of Advanced General Dentistry, Faculty of Dentistry, Mahidol University, Bangkok 10400, Thailand.
Int J Environ Res Public Health. 2021 Aug 19;18(16):8738. doi: 10.3390/ijerph18168738.
This study's objective was to describe the relationship between the main risk factors for oral cancer, including tobacco (in the form of cigarettes, smokeless tobacco (SLT), secondhand smoking (SS)), alcohol, and betel quid (BQ), and the occurrence of oral potentially malignant disorders (OPMDs). A community-based case-control study was conducted with a population of 1448 adults aged 40 years or above in northeastern Thailand. Patients aged 60 years or above (OR 1.79, < 0.001) and female patients (OR 2.17, < 0.001) had a significant chance of having OPMDs. Our multivariate analysis showed that the most potent risk factor for OPMDs occurrence was betel quid (BQ) (adjusted OR 4.65, < 0.001), followed by alcohol (OR 3.40, < 0.001). Even former users were at risk of developing OPMDs. The synergistic effect between these main risk factors was significantly shown in the group exposed to SLT, SS, BQ, and alcohol. The most potent synergistic effect was found in the group exposed to SLT, BQ and alcohol with the OR = 20.96.
本研究旨在描述口腔癌主要危险因素（包括烟草[香烟、无烟气烟草（SLT）、二手烟（SS）]、酒精和槟榔）与口腔潜在恶性疾病（OPMD）发生之间的关系。我们在泰国东北部进行了一项基于社区的病例对照研究，纳入了 1448 名年龄在 40 岁及以上的成年人。年龄在 60 岁及以上的患者（OR 1.79，<0.001）和女性患者（OR 2.17，<0.001）发生 OPMD 的几率显著增加。多变量分析显示，槟榔（BQ）（调整后的 OR 4.65，<0.001）是 OPMD 发生的最强烈危险因素，其次是酒精（OR 3.40，<0.001）。即使是曾经使用者也有发生 OPMD 的风险。这些主要危险因素之间的协同作用在暴露于 SLT、SS、BQ 和酒精的人群中表现显著。在暴露于 SLT、BQ 和酒精的人群中发现了最强的协同作用，OR=20.96。
