Leng Xue, Liu Jing, Han Xiao, Li Te, Ouyang Han, Yan Xia, He Shan
Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, Zhejiang, China.
Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, Zhejiang, China.
Chem Biodivers. 2023 Jan;20(1):e202200966. doi: 10.1002/cbdv.202200966. Epub 2022 Dec 20.
Chemical investigation of the Xisha soft coral Sarcophyton sp. has led to the isolation of eight cembrane-type diterpenoids, including three new compounds, namely sarcophynoids A-C (1-3), and five known analog compounds (4-8). Their structures were clarified based on spectroscopic analysis, and computer-assisted methods including TDDFT-ECD calculation and the quantum mechanical-nuclear magnetic resonance (QM-NMR) method. All the above compounds were tested for their antibacterial activities. Among them, compounds 4-7 and 8 exhibited antibacterial activities against S. aureus, B. subtilis, and P. aeruginosa, with MIC of 4-64 μg/mL.
对西沙软珊瑚肉芝软珊瑚属物种进行化学研究，已分离出8种西松烷型二萜类化合物，包括3个新化合物，即肉芝软珊瑚素A - C（1 - 3），以及5个已知类似化合物（4 - 8）。基于光谱分析以及包括TDDFT - ECD计算和量子力学 - 核磁共振（QM - NMR）方法在内的计算机辅助方法阐明了它们的结构。对上述所有化合物进行了抗菌活性测试。其中，化合物4 - 7和8对金黄色葡萄球菌、枯草芽孢杆菌和铜绿假单胞菌表现出抗菌活性，最低抑菌浓度为4 - 64μg/mL。
