Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, China.
Key Laboratory of Marine Drugs, Chinese Ministry of Education; School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Nat Prod Res. 2023 Jan;37(1):39-46. doi: 10.1080/14786419.2021.1948041. Epub 2021 Sep 27.
Four new cembrane diterpenes, 1,13-di--13-acetoxy launine P (), 13-oxo-thunbergol (), isocrassumol B () and 7α, 8α-sarcophine (), together with two known launine P ( and sarcophytonin B (), were isolated from the extract of the South China Sea soft coral . The structures were elucidated by spectroscopic analysis, ECD analysis and comparison with literature data. All compounds were tested for their antimicrobial activity and antiviral activity. Compounds , and were found to exhibit weak antibacterial activity, while showed strong inhibition activity against and (MIC＜0.5 µg/mL). Compounds showed moderate inhibitory effect against influenza A viruses H1N1 with IC of 17.8 μM.
从南海软珊瑚中分离得到四个新的海松烷二萜类化合物，1,13-二-O-乙酰-13-乙酰氧基拉尼宁 P ()、13-氧-松烯醇 ()、异克拉苏醇 B ()和 7α,8α-鲨肌碱 ()，以及两个已知的拉尼宁 P ()和鲨肌醇 B ()。通过光谱分析、ECD 分析和与文献数据比较，确定了这些化合物的结构。所有化合物均进行了抗菌和抗病毒活性测试。化合物 、 和 表现出较弱的抗菌活性，而 对 和 （MIC＜0.5 μM）表现出较强的抑制活性。化合物 对 H1N1 流感病毒表现出中等抑制作用，IC 为 17.8 μM。
