Nishizawa Toshihiro, Yoshida Shuntaro, Toyoshima Akira, Matsuno Tatsuya, Sakitani Kosuke, Kato Jun, Ebinuma Hirotoshi, Fujishiro Mitsuhiro, Suzuki Hidekazu, Toyoshima Osamu
Gastroenterology, Toyoshima Endoscopy Clinic, 6-17-5 Seijo, Setagaya-ku, Tokyo 157-0066, Japan.
Department of Gastroenterology and Hepatology, International University of Health and Welfare, Narita Hospital, 852 Hatakeda, Narita, Chiba 286-8520, Japan.
J Clin Biochem Nutr. 2022 Nov;71(3):245-248. doi: 10.3164/jcbn.22-56. Epub 2022 Aug 4.
The prevalence of () has decreased during several decades due to improvements in the sanitary environment in Japan. Consequently, a relative increase in the incidence of -uninfected gastric cancer is expected. We analyzed the trends in -uninfected gastric cancer. Two hundred fifty-eight patients with gastric cancer were retrospectively analyzed. The study was divided into four periods: 2008-2011 (first period), 2012-2014 (second period), 2015-2017 (third period), and 2018-2021 (fourth period). The status of infection was divided into four categories: uninfected, successful eradication, spontaneous eradication, and persistent infection. Gastric mucosal atrophy was divided into six grades according to the Kimura-Takemoto classification. The proportion of infections significantly changed over the study period ( = 0.007). In particular, the rate of -uninfected gastric cancer tended to increase over time (0%, 2.9%, 4.9%, and 13.4% in the first, second, third, and fourth periods, respectively; = 0.0013). The rate of no atrophy (C-0) in gastric cancer tended to increase over time (0%, 2.9%, 4.9%, and 11.0% in the first, second, third, and fourth periods, respectively; = 0.0046). In conclusion, the rate of -uninfected gastric cancer without gastric atrophy tended to increase over time.
由于日本卫生环境的改善，几十年来（）的患病率有所下降。因此，预计未感染 - 的胃癌发病率会相对增加。我们分析了未感染 - 的胃癌的趋势。对258例胃癌患者进行了回顾性分析。该研究分为四个时期：2008 - 2011年（第一时期）、2012 - 2014年（第二时期）、2015 - 2017年（第三时期）和2018 - 2021年（第四时期）。感染状况分为四类：未感染、成功根除、自然根除和持续感染。胃黏膜萎缩根据木村 - 竹本分类法分为六个等级。在研究期间，感染的比例有显著变化（ = 0.007）。特别是，未感染 - 的胃癌发生率随时间有上升趋势（第一、第二、第三和第四时期分别为0%、2.9%、4.9%和13.4%； = 0.0013）。胃癌中无萎缩（C - 0）的比例随时间有上升趋势（第一、第二、第三和第四时期分别为0%、2.9%、4.9%和11.0%； = 0.0046）。总之，无胃萎缩的未感染 - 的胃癌发生率随时间有上升趋势。
