Alsarraj Mazin, Alshehri Sami M, Qattan Abdulrahman, Mofti Abdelelah, Wazqer Lana, Bukhari Sumayiah, Shamsaldin Aisha, Rajab Rahaf
Otolaryngology - Head and Neck Surgery, King Fahad General Hospital, Jeddah, SAU.
Otolaryngology - Head and Neck Surgery, King Abdullah Medical Complex, Jeddah, SAU.
Cureus. 2022 Oct 27;14(10):e30780. doi: 10.7759/cureus.30780. eCollection 2022 Oct.
In the treatment of various patients, the presence of lymphovascular invasion is a prognostic determinant, often taken into account by surgeons and oncologists. The exact frequency and prognostic impacts of this microscopic event in adenoid cystic carcinoma (ACC) patients are, however, not clear. This systematic review and meta-analysis aimed to investigate the lymph node involvement and the clinical stage of cancer as predictors of ACC prognosis. A systematic search was conducted covering a number of databases, including PubMed, Science Direct, Google Scholar, Web of Science, and EBSCO. A total of three studies were included in this analysis, with 591 participants, 247 of whom were males. Lymph node involvement and clinical stage were demonstrated as significant bad prognosis factors among ACC patients (HR = 1.48, 95% CI, 1.00, 1.96; P<0.0001). We found that lymph node involvement and clinical stage of the cancer are both significant predictors of bad prognosis of ACC.
在各类患者的治疗中，淋巴管浸润的存在是一个预后决定因素，外科医生和肿瘤学家通常会予以考虑。然而，在腺样囊性癌（ACC）患者中，这种微观事件的确切发生率及其对预后的影响尚不清楚。本系统评价和荟萃分析旨在研究淋巴结受累情况和癌症临床分期作为ACC预后的预测指标。我们进行了系统检索，涵盖多个数据库，包括PubMed、Science Direct、谷歌学术、科学网和EBSCO。本分析共纳入三项研究，591名参与者，其中247名男性。在ACC患者中，淋巴结受累和临床分期被证明是显著的不良预后因素（HR = 1.48，95%CI，1.00，1.96；P<0.0001）。我们发现，癌症的淋巴结受累情况和临床分期均是ACC不良预后的显著预测指标。
