Neonatal Intensive Care Unit, San Cecilio Clinical Hospital, Granada, Spain.
Ophthalmology Department, Ophthalmology Service, San Cecilio Clinical Hospital, Granada, Spain.
Am J Perinatol. 2024 May;41(S 01):e430-e434. doi: 10.1055/s-0042-1755464. Epub 2022 Nov 30.
This article describes the results of a study investigating the sensitivity and specificity of the Newborn Infant Parasympathetic Evaluation (NIPE) index for detecting the physiological changes resulting from nociception in painful procedures in very low birth weight (VLBW) infants.
A prospective observational study was carried on of 44 newborns at 23 to 32 weeks' gestational age. The sensitivity and specificity of the NIPE index are analyzed using a receiver operating characteristic curve. Most of the painful procedures performed were skin-lancing and venipunctures. Nonpainful procedures consist of no intervention, with an interval of at least 1 hour with painful procedures in each newborn.
The accuracy of the NIPE index to diagnose mild nociceptive stimulation in VLBW newborns is 73.2%.
The NIPE index is a useful technique for assessing nociceptive stimulation in newborns, presenting less observer-dependent variability than other pain assessment scales.
· The NIPE index offers an objective assessment of pain.. · Moderate-high sensitivity of the NIPE index in the evaluation of pain in premature newborns.. · Painful procedures in VLBW newborns are reflected as a decrease in the NIPE score..
本文描述了一项研究的结果，该研究调查了新生儿副交感神经评价（NIPE）指数在检测极低出生体重（VLBW）婴儿疼痛过程中生理变化的敏感性和特异性。
对 44 名 23 至 32 周胎龄的新生儿进行前瞻性观察研究。使用受试者工作特征曲线分析 NIPE 指数的敏感性和特异性。大多数进行的疼痛程序是皮肤划痕和静脉穿刺。非疼痛程序包括无干预，在每个新生儿中，与疼痛程序至少间隔 1 小时。
NIPE 指数诊断 VLBW 新生儿轻度伤害性刺激的准确性为 73.2%。
NIPE 指数是一种评估新生儿伤害性刺激的有用技术，与其他疼痛评估量表相比，观察者间的变异性更小。
·NIPE 指数提供了疼痛的客观评估。·NIPE 指数在评估早产儿疼痛方面具有较高的敏感性。·VLBW 新生儿的疼痛程序反映为 NIPE 评分降低。
