El Gendy Yasmine Gamal Abdou, Abdel Wahed Mohammad Ashraf, Ragab Mostafa Hussein Hassan, Awad Yosra Mohamed Mohsen
Department of Pediatrics, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
Pediatr Gastroenterol Hepatol Nutr. 2022 Nov;25(6):510-518. doi: 10.5223/pghn.2022.25.6.510. Epub 2022 Nov 2.
Recently, great interest has been focused on dietary fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) for the treatment of functional abdominal pain (FAP). Several meta-analyses, including those on the adult population, have been published, potentiating its role. However, pediatric studies are scarce. We aimed to evaluate the effect of a low-FODMAP diet on the severity of FAP in children.
This clinical trial included 50 patients aged 3-18 years with irritable bowel syndrome and FAP that were not otherwise specified. The patients were instructed to receive a low FODMAP diet guided by a dietitian. The primary outcome was the percentage of responders after 2 months of dietary intervention compared with baseline. Other outcomes included changes in stool consistency and quality of life (QoL) scores using the KIDSCREEN-10 questionnaire, and weight-for-age z-scores.
After the dietary intervention, 74% of patients showed more than 30% lower pain intensity, as examined using the Wong-Baker Faces pain rating scale. Their QoL significantly improved, and patients have gained weight.
A low FODMAP diet can improve pain intensity and QoL among children with functional abdominal pain, with no detrimental effects on body weight.
最近，膳食中可发酵的低聚糖、双糖、单糖和多元醇（FODMAPs）在功能性腹痛（FAP）治疗方面备受关注。包括针对成人人群的多项荟萃分析已经发表，强化了其作用。然而，儿科研究较少。我们旨在评估低FODMAP饮食对儿童FAP严重程度的影响。
这项临床试验纳入了50例年龄在3至18岁之间、患有未另作说明的肠易激综合征和FAP的患者。患者在营养师指导下接受低FODMAP饮食。主要结局是与基线相比，饮食干预2个月后有反应者的百分比。其他结局包括使用KIDSCREEN - 10问卷评估的粪便稠度变化、生活质量（QoL）评分以及年龄别体重z评分。
饮食干预后，使用面部表情疼痛评分量表（Wong - Baker Faces pain rating scale）检查发现，74%的患者疼痛强度降低了30%以上。他们的生活质量显著改善，且患者体重增加。
低FODMAP饮食可改善功能性腹痛儿童的疼痛强度和生活质量，且对体重无不良影响。
