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低可发酵寡糖、双糖、单糖和多元醇饮食对小儿功能性腹痛症状的影响。

Effects of a Low-Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyol Diet on Symptoms of Functional Abdominal Pain in Pediatric Patients.

作者信息

El Gendy Yasmine Gamal Abdou, Abdel Wahed Mohammad Ashraf, Ragab Mostafa Hussein Hassan, Awad Yosra Mohamed Mohsen

机构信息

Department of Pediatrics, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.

出版信息

Pediatr Gastroenterol Hepatol Nutr. 2022 Nov;25(6):510-518. doi: 10.5223/pghn.2022.25.6.510. Epub 2022 Nov 2.

Abstract

PURPOSE

Recently, great interest has been focused on dietary fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) for the treatment of functional abdominal pain (FAP). Several meta-analyses, including those on the adult population, have been published, potentiating its role. However, pediatric studies are scarce. We aimed to evaluate the effect of a low-FODMAP diet on the severity of FAP in children.

METHODS

This clinical trial included 50 patients aged 3-18 years with irritable bowel syndrome and FAP that were not otherwise specified. The patients were instructed to receive a low FODMAP diet guided by a dietitian. The primary outcome was the percentage of responders after 2 months of dietary intervention compared with baseline. Other outcomes included changes in stool consistency and quality of life (QoL) scores using the KIDSCREEN-10 questionnaire, and weight-for-age z-scores.

RESULTS

After the dietary intervention, 74% of patients showed more than 30% lower pain intensity, as examined using the Wong-Baker Faces pain rating scale. Their QoL significantly improved, and patients have gained weight.

CONCLUSION

A low FODMAP diet can improve pain intensity and QoL among children with functional abdominal pain, with no detrimental effects on body weight.

摘要

目的

最近,膳食中可发酵的低聚糖、双糖、单糖和多元醇(FODMAPs)在功能性腹痛(FAP)治疗方面备受关注。包括针对成人人群的多项荟萃分析已经发表,强化了其作用。然而,儿科研究较少。我们旨在评估低FODMAP饮食对儿童FAP严重程度的影响。

方法

这项临床试验纳入了50例年龄在3至18岁之间、患有未另作说明的肠易激综合征和FAP的患者。患者在营养师指导下接受低FODMAP饮食。主要结局是与基线相比,饮食干预2个月后有反应者的百分比。其他结局包括使用KIDSCREEN - 10问卷评估的粪便稠度变化、生活质量(QoL)评分以及年龄别体重z评分。

结果

饮食干预后,使用面部表情疼痛评分量表(Wong - Baker Faces pain rating scale)检查发现,74%的患者疼痛强度降低了30%以上。他们的生活质量显著改善,且患者体重增加。

结论

低FODMAP饮食可改善功能性腹痛儿童的疼痛强度和生活质量,且对体重无不良影响。

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本文引用的文献

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Is low FODMAP diet effective in children with irritable bowel syndrome?低FODMAP饮食对肠易激综合征患儿有效吗?
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Paediatric functional abdominal pain disorders.儿科功能性腹痛障碍。
Nat Rev Dis Primers. 2020 Nov 5;6(1):89. doi: 10.1038/s41572-020-00222-5.
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Irritable bowel syndrome.肠易激综合征。
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