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苯并(a)芘通过影响胎盘组织中IL-18和IL-1RN的表达诱导不良妊娠结局。

Benzo(a)pyrene induced adverse pregnancy outcomes by affecting the expression of IL-18 and IL-1RN in placenta.

作者信息

Xu Feibo, Cai Heng, Li Hongxing, Wang Dong

机构信息

Department of Histology and Embryology, Binzhou Medical University, Yantai 264003, Shandong, China.

Department of Histology and Embryology, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, 250117, Shandong, China.

出版信息

Heliyon. 2022 Nov 21;8(11):e11767. doi: 10.1016/j.heliyon.2022.e11767. eCollection 2022 Nov.

DOI:10.1016/j.heliyon.2022.e11767
PMID:36451752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9703611/
Abstract

AIMS

Inflammatory cytokines can destroy the immune balance and lead to adverse pregnancy outcomes. Benzo (a) pyrene (BaP) may induce premature delivery through leading inflammatory reaction. We screened out inflammatory factors related to adverse pregnancy outcomes through bioinformatics analysis. Then we verified the correlation between adverse pregnancy outcomes caused by BaP and abnormal expression of those inflammatory factors.

MAIN METHODS

The Gene Expression Omnibus (GEO) database was used to analyze by R to screen the inflammatory genes related to adverse pregnancy outcomes. Based on the established BaP exposure animal model, the expression of key cytokines in placenta was detected by immunohistochemistry.

KEY FINDINGS

According to the data analysis of GEO database, the expression of , and was up-regulated, while the expression of was down regulated in the adverse pregnancy outcome group. BaP exposure significantly increased the rate of adverse pregnancy outcome in pregnant golden hamsters, and also significantly interferes with the process of embryonic development. Meanwhile, the expression of IL18, IL18BP and IL18R in placenta was increased, while the expression of IL1RN protein was decreased, consistent with the mRNA expression level gathered by bioinformatics analysis.

SIGNIFICANCE

BaP may induce the inflammatory reaction to cause adverse pregnancy outcome by regulating the expression of IL18, IL18BP, IL18R and IL1RN. Our findings provide experimental basis for the prevention of adverse pregnancy outcome caused by BaP.

摘要

目的

炎性细胞因子可破坏免疫平衡并导致不良妊娠结局。苯并（a）芘（BaP）可能通过引发炎症反应诱导早产。我们通过生物信息学分析筛选出与不良妊娠结局相关的炎性因子。然后我们验证了BaP导致的不良妊娠结局与这些炎性因子异常表达之间的相关性。

主要方法

使用基因表达综合数据库（GEO）通过R进行分析，以筛选与不良妊娠结局相关的炎性基因。基于建立的BaP暴露动物模型，通过免疫组织化学检测胎盘关键细胞因子的表达。

主要发现

根据GEO数据库的数据分析，在不良妊娠结局组中，[此处原文缺失具体基因名称]的表达上调，而[此处原文缺失具体基因名称]的表达下调。BaP暴露显著增加了妊娠金黄地鼠的不良妊娠结局发生率，并且还显著干扰胚胎发育过程。同时，胎盘中IL18、IL18BP和IL18R的表达增加，而IL1RN蛋白的表达降低，这与通过生物信息学分析收集的mRNA表达水平一致。

意义

BaP可能通过调节IL18、IL18BP、IL18R和IL1RN的表达诱导炎症反应，从而导致不良妊娠结局。我们的研究结果为预防BaP引起的不良妊娠结局提供了实验依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd15/9703611/7159b9723920/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd15/9703611/e354418d7930/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd15/9703611/e8f19296e26d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd15/9703611/5c22509806a4/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd15/9703611/61edfec87f3a/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd15/9703611/e1ffa98f1474/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd15/9703611/b1027b38293c/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd15/9703611/1747cc70060a/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd15/9703611/7159b9723920/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd15/9703611/e354418d7930/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd15/9703611/e8f19296e26d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd15/9703611/5c22509806a4/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd15/9703611/61edfec87f3a/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd15/9703611/e1ffa98f1474/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd15/9703611/b1027b38293c/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd15/9703611/1747cc70060a/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd15/9703611/7159b9723920/gr8.jpg

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本文引用的文献

1
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Environ Health Perspect. 2021 Nov;129(11):117001. doi: 10.1289/EHP9256. Epub 2021 Nov 8.
2
The role of Interleukin-18 in recurrent early pregnancy loss.白细胞介素-18 在复发性早期妊娠丢失中的作用。
J Reprod Immunol. 2021 Nov;148:103432. doi: 10.1016/j.jri.2021.103432. Epub 2021 Oct 5.
3
Chorioamnionitis and neonatal outcomes.绒毛膜羊膜炎与新生儿结局。
Pediatr Res. 2022 Jan;91(2):289-296. doi: 10.1038/s41390-021-01633-0. Epub 2021 Jul 1.
4
Interleukin-18, IL-18 binding protein and IL-18 receptor expression in asthma: a hypothesis showing IL-18 promotes epithelial cell differentiation.白细胞介素-18、IL-18结合蛋白及IL-18受体在哮喘中的表达：一项表明IL-18促进上皮细胞分化的假说
Clin Transl Immunology. 2021 Jun 26;10(6):e1301. doi: 10.1002/cti2.1301. eCollection 2021.
5
Human Autoinflammatory Diseases Mediated by NLRP3-, Pyrin-, NLRP1-, and NLRC4-Inflammasome Dysregulation Updates on Diagnosis, Treatment, and the Respective Roles of IL-1 and IL-18.NLRP3、Pyrin、NLRP1 和 NLRC4 炎性体失调介导的人类自身炎症性疾病：诊断、治疗的最新进展及 IL-1 和 IL-18 的各自作用。
Front Immunol. 2020 Aug 25;11:1840. doi: 10.3389/fimmu.2020.01840. eCollection 2020.
6
Cigarette smoke induced neural tube defects by down-regulating noggin expression.香烟烟雾通过下调 noggin 表达诱导神经管缺陷。
Birth Defects Res. 2021 Jan 1;113(1):5-13. doi: 10.1002/bdr2.1804. Epub 2020 Sep 19.
7
The alarmin interleukin-1α causes preterm birth through the NLRP3 inflammasome.警报素白细胞介素-1α 通过 NLRP3 炎性小体引起早产。
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8
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9
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10
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Environ Pollut. 2020 Sep;264:114790. doi: 10.1016/j.envpol.2020.114790. Epub 2020 May 11.