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TLE3的泛癌分析揭示了其在肿瘤微环境和预后中的价值。

Pan-Cancer Analysis of TLE3 Revealed Its Value in Tumor Microenvironment and Prognosis.

作者信息

Li Tianyu, Liu Ranran, Zhang Guohong, Jia Yejuan, Pan Lijia, Li Yunfeng, Jia Chunsheng

机构信息

School of Acupuncture, Moxibustion and Tuina, Hebei University of Chinese Medicine, Shijiazhuang 050200, China.

Department of Biochemistry and M Biology, College of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang 050200, China.

出版信息

J Oncol. 2022 Nov 21;2022:4085770. doi: 10.1155/2022/4085770. eCollection 2022.

DOI:10.1155/2022/4085770
PMID:36451774
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9705091/
Abstract

BACKGROUND

Transducin-like enhancer of split 3 (TLE3), a member of the TLE gene family, is related to tumor genesis and progression. However, whether TLE3 played a crucial role in the whole pan-cancer remained unknown.

METHODS

Comprehensive analysis of TCGA, GEO, and GTEx data with an online tool, and language was performed to explore the relationship of TLE3 expression between prognosis, gene mutation, protein phosphorylation, DNA methylation, tumor microenvironment, and related pathways in 33 tumors.

RESULTS

TLE3 was high-expressed in most tumors, and TLE3 expression and the prognosis of some tumor types were significantly correlated. The level of TLE3 expression in 33 cancer types was closely associated with DNA methylation. High-level phosphorylation sites of Tle3, such as S267 and S217, may promote cancers. In terms of the tumor microenvironment, TLE3 affected a wide variety of cancers, especially PRAD and LIHC, and TLE3 may act on them via immune-related pathways.

CONCLUSIONS

The current work provided the first comprehensive investigation of TLE3 in a pan-cancer study, highlighting the role of TLE3 in the tumor immune microenvironment, and also determined the potential of TLE3 as a prognostic, immunotherapy response, and diagnostic biomarker in many cancers. However, the present results were preliminary and required further validation as this study was based on bioinformatics analyses.

摘要

背景

分裂样增强子3（TLE3）是TLE基因家族的成员，与肿瘤的发生和发展有关。然而，TLE3在整个泛癌中是否起关键作用尚不清楚。

方法

使用在线工具对TCGA、GEO和GTEx数据进行综合分析，并进行语言分析，以探讨33种肿瘤中TLE3表达与预后、基因突变、蛋白磷酸化、DNA甲基化、肿瘤微环境及相关通路之间的关系。

结果

TLE3在大多数肿瘤中高表达，且TLE3表达与某些肿瘤类型的预后显著相关。33种癌症类型中TLE3的表达水平与DNA甲基化密切相关。Tle3的高水平磷酸化位点，如S267和S217，可能促进癌症。在肿瘤微环境方面，TLE3影响多种癌症，尤其是前列腺癌（PRAD）和肝细胞癌（LIHC），且TLE3可能通过免疫相关途径作用于它们。

结论

目前的工作在泛癌研究中首次对TLE3进行了全面研究，突出了TLE3在肿瘤免疫微环境中的作用，还确定了TLE3作为许多癌症的预后、免疫治疗反应和诊断生物标志物的潜力。然而，由于本研究基于生物信息学分析，目前的结果是初步的，需要进一步验证。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38da/9705091/91ba425fbd73/JO2022-4085770.011.jpg
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