人工智能与CRISPR/Cas9系统在疫苗设计中的整合
Integration of Artificial Intelligence and CRISPR/Cas9 System for Vaccine Design.
作者信息
Maserat Elham
机构信息
Department of Medical Informatics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
出版信息
Cancer Inform. 2022 Nov 26;21:11769351221140102. doi: 10.1177/11769351221140102. eCollection 2022.
Abstract
The CRISPR/Cas9 system offers a new approach to genome editing and cancer treatment. This approach is able to detect drug targets and genomic analysis of cancer. The use of artificial intelligence (AI) capacity to edit genomes through CRISPR/Cas9 enables modification of gene mutations, molecular simulation. AI approaches include knowledge discovery approaches, antigen and epitope prediction approaches, and agent based-model approaches. These methods in combination with CRISPR/Cas9 can be used in vaccine design.
摘要
CRISPR/Cas9系统为基因组编辑和癌症治疗提供了一种新方法。这种方法能够检测癌症的药物靶点并进行基因组分析。利用人工智能（AI）通过CRISPR/Cas9编辑基因组的能力能够实现基因突变的修饰和分子模拟。AI方法包括知识发现方法、抗原和表位预测方法以及基于智能体的模型方法。这些方法与CRISPR/Cas9相结合可用于疫苗设计。
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