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Lipid-Based Intelligent Vehicle Capabilitized with Physical and Physiological Activation.

作者信息

Zhang Fuxue, Xia Bozhang, Sun Jiabei, Wang Yufei, Wang Jinjin, Xu Fengfei, Chen Junge, Lu Mei, Yao Xin, Timashev Peter, Zhang Yuanyuan, Chen Meiwan, Che Jing, Li Fangzhou, Liang Xing-Jie

机构信息

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, No. 11, First North Road, Zhongguancun, Beijing 100190, China.

Sino-Danish Center for Education and Research, Sino-Danish College of University of Chinese Academy of Sciences, Beijing 100049, China.

出版信息

Research (Wash D C). 2022 Oct 31;2022:9808429. doi: 10.34133/2022/9808429. eCollection 2022.

DOI:10.34133/2022/9808429
PMID:36452433
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9680525/
Abstract

Intelligent drug delivery system based on "stimulus-response" mode emerging a promising perspective in next generation lipid-based nanoparticle. Here, we classify signal sources into physical and physiological stimulation according to their origin. The physical signals include temperature, ultrasound, and electromagnetic wave, while physiological signals involve pH, redox condition, and associated proteins. We first summarize external physical response from three main points about efficiency, particle state, and on-demand release. Afterwards, we describe how to design drug delivery using the physiological environment in vivo and present different current application methods. Lastly, we draw a vision of possible future development.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d2/9680525/aeb2848d2bb4/RESEARCH2022-9808429.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d2/9680525/ea63625b3571/RESEARCH2022-9808429.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d2/9680525/9c38d01ebbb7/RESEARCH2022-9808429.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d2/9680525/4329b77f2842/RESEARCH2022-9808429.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d2/9680525/d2e5cbb882b0/RESEARCH2022-9808429.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d2/9680525/27c0f23f5937/RESEARCH2022-9808429.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d2/9680525/1bdc66ba41f7/RESEARCH2022-9808429.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d2/9680525/cce8468e1f0f/RESEARCH2022-9808429.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d2/9680525/58bd3bd6edb8/RESEARCH2022-9808429.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d2/9680525/be9fd2c785fb/RESEARCH2022-9808429.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d2/9680525/aeb2848d2bb4/RESEARCH2022-9808429.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d2/9680525/ea63625b3571/RESEARCH2022-9808429.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d2/9680525/9c38d01ebbb7/RESEARCH2022-9808429.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d2/9680525/4329b77f2842/RESEARCH2022-9808429.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d2/9680525/d2e5cbb882b0/RESEARCH2022-9808429.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d2/9680525/27c0f23f5937/RESEARCH2022-9808429.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d2/9680525/1bdc66ba41f7/RESEARCH2022-9808429.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d2/9680525/cce8468e1f0f/RESEARCH2022-9808429.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d2/9680525/58bd3bd6edb8/RESEARCH2022-9808429.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d2/9680525/be9fd2c785fb/RESEARCH2022-9808429.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d2/9680525/aeb2848d2bb4/RESEARCH2022-9808429.010.jpg

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本文引用的文献

[1]
Membrane-destabilizing ionizable lipid empowered imaging-guided siRNA delivery and cancer treatment.

Exploration (Beijing). 2021-9-1

[2]
Mitochondria-specific nanocatalysts for chemotherapy-augmented sequential chemoreactive tumor therapy.

Exploration (Beijing). 2021-9-1

[3]
Carrier strategies boost the application of CRISPR/Cas system in gene therapy.

Exploration (Beijing). 2022-3-15

[4]
Ultrasound-controlled drug release and drug activation for cancer therapy.

Exploration (Beijing). 2021-12-28

[5]
Taking phototherapeutics from concept to clinical launch.

Nat Rev Chem. 2021-11

[6]
Current advances in the use of exosomes, liposomes, and bioengineered hybrid nanovesicles in cancer detection and therapy.

Acta Pharmacol Sin. 2022-11

[7]
Physical & Chemical Microwave Ablation (MWA) Enabled by Nonionic MWA Nanosensitizers Repress Incomplete MWA-Arised Liver Tumor Recurrence.

ACS Nano. 2022-4-26

[8]
On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles.

Proc Natl Acad Sci U S A. 2021-12-28

[9]
Ultrasound triggered topical delivery of Bmp7 mRNA for white fat browning induction via engineered smart exosomes.

J Nanobiotechnology. 2021-12-4

[10]
Thrombin Based Photothermal-Responsive Nanoplatform for Tumor-Specific Embolization Therapy.

Small. 2021-12

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