Thota Ramya, Aggarwal Sadhna, Chirom Amit Singh, Thakar Alok, Gupta Siddhartha Dutta, Sharma Suresh C, Das Satya N
Department of Otorhinolaryngology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029 India.
Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029 India.
Indian J Otolaryngol Head Neck Surg. 2022 Oct;74(Suppl 2):2027-2032. doi: 10.1007/s12070-020-01980-0. Epub 2020 Jul 23.
Survivin, an inhibitor of apoptosis protein is a biomarker of significance in prognostication of many malignancies. In the current study we investigated the serum survivin levels in patients with oral submucosal fibrosis (OSMF) and squamous cell carcinoma (OSCC). Serum was isolated from, peripheral blood collected of clinically and histopathologically confirmed OSMF and OSCC patients. Circulating level of survivin was measured in patients and control subjects by ELISA and analyzed further using Kruskal-Wallis test and two-sample Wilcoxon rank-sum (Mann-Whitney) test. Serum Survivin levels were significantly reduced in the OSCC group as compared to the control group. No significant correlation was noted between the serum survivin level and various clinicopathological characteristics of OSCC and OSMF patients. Our study suggests that free, wild form of circulating survivin probably has no role in predicting the prognosis of oral cancer or the malignant transformation potential of oral submucosal fibrosis.
生存素作为一种凋亡抑制蛋白，是许多恶性肿瘤预后的重要生物标志物。在本研究中，我们调查了口腔黏膜下纤维化（OSMF）和鳞状细胞癌（OSCC）患者的血清生存素水平。从临床和组织病理学确诊的OSMF和OSCC患者采集的外周血中分离血清。通过酶联免疫吸附测定（ELISA）法测定患者和对照受试者的循环生存素水平，并进一步使用Kruskal-Wallis检验和双样本Wilcoxon秩和（Mann-Whitney）检验进行分析。与对照组相比，OSCC组的血清生存素水平显著降低。未发现血清生存素水平与OSCC和OSMF患者的各种临床病理特征之间存在显著相关性。我们的研究表明，游离的、野生型的循环生存素可能在预测口腔癌预后或口腔黏膜下纤维化的恶性转化潜能方面不起作用。
