原癌基因在致癌过程中的意义。

The significance of proto-oncogenes in carcinogenesis.

作者信息

Rosen P

出版信息

Med Hypotheses. 1987 Jan;22(1):23-6. doi: 10.1016/0306-9877(87)90004-1.

Abstract

A survey of the literature on activated proto-oncogenes shows that they are involved in the development of cancer but apparently not in the initiation process. The review of Klein and Klein comes to conclusions in opposition to the review of Duesberg. I favor the latter here. Active proto-oncogenes may be part of the developmental process of carcinogenesis but are not initiators of carcinogenesis.

摘要

一项关于活化原癌基因的文献调查表明，它们参与癌症的发展，但显然不参与启动过程。克莱因和克莱因的综述得出的结论与杜斯伯格的综述相反。在此我支持后者。活跃的原癌基因可能是致癌作用发展过程的一部分，但不是致癌作用的启动因素。