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特发性脑脊液漏的CT脑池造影表现,重点关注长期管理

CT Cisternogram Findings in Idiopathic Cerebrospinal Fluid Leaks with Emphasis on Long Term Management.

作者信息

Velusamy Anand, Anand Aishwarya, Hameed Nazrin

机构信息

MCV ENT Centre, Coimbatore, Tamil Nadu India.

出版信息

Indian J Otolaryngol Head Neck Surg. 2022 Oct;74(Suppl 2):1605-1611. doi: 10.1007/s12070-021-02766-8. Epub 2021 Jul 21.

Abstract

To study the various computed tomography (CT) cisternogram findings in idiopathic cerebrospinal fluid (CSF) leaks and the long term treatment modalities after surgical repair of idiopathic CSF leaks. This was a descriptive study conducted among 25 patients in MCV memorial ENT trust hospital, Pollachi between May 2014 and May 2020 amongst patients who underwent CT cisternogram for unilateral or bilateral spontaneous rhinorrhea with or without associated headache, visual disturbances and papilloedema diagnosed to be idiopathic CSF leak by investigations. These patients then underwent CSF leak repair and postoperatively were managed with weight reduction, low salt diet and diuretic therapy. Post surgery these patients were followed up for a period of 12 months and were evaluated on the basis of presence or absence of headache, rhinorrhea and papilloedema at the end of 1st month, 3rd month, 6th month and 1 year and data was collected. CT cisternogram findings were evaluated by proportion method and evaluation of long term management was done using proportion and repeated measures ANOVA for all patients. Evidence of the presence of previously mentioned CT cisternogram or contrast MRI findings at the end of 1 year of post-surgical treatment was recorded where patients were willing for the same. CT Cisternography was done for all patients and 72% patients had empty sella appearance while 28% had partially empty sella. Other findings included perioptic filling, optic blunting and arachnoid pits which were found in 11(44%), 8(32%) and 12(48%) of patients respectively. Only 3(12%) out of 25 patients had an encephalocoele. The commonest site of leak in CT cisternography was the cribriform plate (52%) followed by lateral recess of sphenoid (48%). None of the patients had multiple sites of leak in CT cisternography. On follow up post surgery maximum resolution of symptoms was found at the end of 12 months where 23 out of 25 patients improved. In our study, out of 25 only 5 patients agreed to undergo post diuretic therapy MRI scan out of which 2 patients had partially empty sella and 3 had normal sella indicating resolution of BIH. CT cisternography is an important investigation which aids in the diagnosis of CSF rhinorrhea due to idiopathic intracranial hypertension (IIH). The medical management of IIH post surgery such as weight reduction, salt restriction and diuretic therapy is also crucial to prevent recurrence of symptoms.

摘要

研究特发性脑脊液漏的各种计算机断层扫描(CT)脑池造影表现以及特发性脑脊液漏手术修复后的长期治疗方式。这是一项描述性研究,于2014年5月至2020年5月在Pollachi的MCV纪念耳鼻喉信托医院对25例患者进行,这些患者因单侧或双侧自发性鼻漏伴或不伴有相关头痛、视觉障碍和视乳头水肿接受了CT脑池造影检查,经检查诊断为特发性脑脊液漏。这些患者随后接受了脑脊液漏修复手术,术后通过减重、低盐饮食和利尿剂治疗进行管理。手术后对这些患者进行了12个月的随访,并在第1个月、第3个月、第6个月和1年结束时根据是否存在头痛、鼻漏和视乳头水肿进行评估并收集数据。通过比例法评估CT脑池造影表现,并使用比例法和重复测量方差分析对所有患者进行长期管理评估。记录了术后1年时愿意接受检查的患者中出现上述CT脑池造影或对比磁共振成像(MRI)表现的证据。所有患者均进行了CT脑池造影,72%的患者表现为空蝶鞍,28%的患者表现为部分空蝶鞍。其他表现包括视周充盈、视神经变钝和蛛网膜小凹,分别在11例(44%)、8例(32%)和12例(48%)患者中发现。25例患者中只有3例(12%)有脑膨出。CT脑池造影中最常见的漏出部位是筛板(52%),其次是蝶骨外侧隐窝(48%)。CT脑池造影中没有患者有多个漏出部位。术后随访发现,25例患者中有23例在12个月结束时症状得到最大程度缓解。在我们的研究中,25例患者中只有5例同意在利尿剂治疗后接受MRI扫描,其中2例患者表现为部分空蝶鞍,3例患者蝶鞍正常,表明良性颅内高压(BIH)得到缓解。CT脑池造影是一项重要的检查,有助于诊断特发性颅内高压(IIH)引起的脑脊液鼻漏。IIH术后的医学管理,如减重、限盐和利尿剂治疗对于预防症状复发也至关重要。

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CT Cisternogram Findings in Idiopathic Cerebrospinal Fluid Leaks with Emphasis on Long Term Management.特发性脑脊液漏的CT脑池造影表现,重点关注长期管理
Indian J Otolaryngol Head Neck Surg. 2022 Oct;74(Suppl 2):1605-1611. doi: 10.1007/s12070-021-02766-8. Epub 2021 Jul 21.
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本文引用的文献

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Imaging of Cerebrospinal Fluid Rhinorrhea and Otorrhea.脑脊液鼻漏和耳漏的影像学检查
Radiol Clin North Am. 2017 Jan;55(1):167-187. doi: 10.1016/j.rcl.2016.08.005.
2
Brain Imaging in Idiopathic Intracranial Hypertension.特发性颅内高压的脑成像
J Neuroophthalmol. 2015 Dec;35(4):400-11. doi: 10.1097/WNO.0000000000000303.
9
Significance of empty sella in cerebrospinal fluid leaks.空蝶鞍在脑脊液漏中的意义。
Otolaryngol Head Neck Surg. 2003 Jan;128(1):32-8. doi: 10.1067/mhn.2003.43.

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