Abbas Waseem, Gupta Saurabh, Goel Vineeta, Aggarwal Anjali
Max Institute of Cancer Care, Shalimar Bagh, Max Super Speciality Hospital Shalimar Bagh, FC-50 C & D Block, Shalimar Bagh, New Delhi, 110008 India.
Indian J Otolaryngol Head Neck Surg. 2022 Oct;74(Suppl 2):2122-2128. doi: 10.1007/s12070-020-02020-7. Epub 2020 Aug 7.
To investigate the incidence of occult neck metastasis and to determine the prognostic factors related to the occurrence of the cervical lymph nodal metastasis and extra capsular extension (ECE) in early oral cavity cancer patients. A retrospective review performed on 100 patients with node negative squamous cell carcinoma of oral cavity who underwent primary treatment between Jan 2015 and Dec 2018. Incidence of occult neck metastasis after the elective neck dissection in our study was 35%. Independent correlates of positive occult neck metastasis were lymphovascular Invasion (P-0.000)[CI 0.004-0.326] and depth of invasion(P-0.009)[CI 0.509-13.428] on univariate analysis and statistically significant factors associated with the incidence of the extracapsular extension were age(P-0.044), lymphovascular invasion(P-0.018)[CI 0.004-0.603] and lymph node ratio(P-0.000)[CI 4.570-158.45] on univariate analysis. Lymphovascular invasion and depth of invasion correlated significantly with occurrence of neck metastasis. Age and LVI were the prognostic factors for extra capsular spread.
研究早期口腔癌患者隐匿性颈部转移的发生率，并确定与颈部淋巴结转移及包膜外扩展（ECE）发生相关的预后因素。对2015年1月至2018年12月期间接受初次治疗的100例口腔鳞状细胞癌且颈部淋巴结阴性患者进行回顾性研究。在我们的研究中，选择性颈清扫术后隐匿性颈部转移的发生率为35%。单因素分析显示，隐匿性颈部转移阳性的独立相关因素为淋巴管侵犯（P=0.000）[可信区间0.004 - 0.326]和浸润深度（P=0.009）[可信区间0.509 - 13.428]；单因素分析显示，与包膜外扩展发生率相关的具有统计学意义的因素为年龄（P=0.044）、淋巴管侵犯（P=0.018）[可信区间0.004 - 0.603]和淋巴结比例（P=0.000）[可信区间4.570 - 158.45]。淋巴管侵犯和浸润深度与颈部转移的发生显著相关。年龄和淋巴管侵犯是包膜外扩散的预后因素。
