Kim Min Jae, Ahn Kang-Min
Department of Oral and Maxillofacial Surgery, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, South Korea.
Maxillofac Plast Reconstr Surg. 2024 Mar 4;46(1):8. doi: 10.1186/s40902-024-00410-3.
Oral squamous cell carcinoma has a poor prognosis. Therefore, prognostic factors are important to increase the survival rate. This study assessed the survival rate and the prognostic factors for survival of patients with oral squamous cell carcinoma.
This study included 168 patients who underwent surgery for oral squamous cell carcinoma between January 2006 and December 2021. The survival rate was analyzed with overall survival and disease-specific survival. The patient's age, sex, pTNM stage, primary sites (lip, tongue, mouth of floor, mandibular gingiva, maxillary gingiva, mandibular vestibule, maxillary vestibule, retromolar trigone, palate, buccal mucosa, primary intra-osseous site), smoking and alcohol drinking habits, depth of invasion, perineural and lymphovascular invasion, cell differentiation, and postoperative radiotherapy were evaluated to analyze risk factors. Kaplan-Meier methods were used to estimate the survival rates. Cox regression methods were used to investigate the main independent predictors of survival in univariable and multivariable analysis.
Sixty-eight patients died of oral squamous cell carcinoma during follow-up periods. Their overall survival for 5 years was 51.2%, and the disease-specific survival was 59.2%. In univariable analysis, seven factors which are neck metastasis, depth of invasion, cell differentiation, lymphovascular invasion, postoperative radiotherapy, pTNM stage, and recurrence were significantly associated with survival. In multivariable analysis, pTNM stage and recurrence were significantly associated with survival.
In patients with oral squamous cell carcinoma, pTNM stage and recurrence were significant prognostic factors. Neck metastasis, depth of invasion, cell differentiation, lymphovascular invasion, and postoperative radiotherapy were also prognostic factors. These factors serve as markers for obtaining prognosis information in oral squamous cell carcinoma.
口腔鳞状细胞癌预后较差。因此，预后因素对于提高生存率很重要。本研究评估了口腔鳞状细胞癌患者的生存率及生存预后因素。
本研究纳入了2006年1月至2021年12月期间接受口腔鳞状细胞癌手术的168例患者。通过总生存和疾病特异性生存分析生存率。评估患者的年龄、性别、pTNM分期、原发部位（唇、舌、口底、下颌牙龈、上颌牙龈、下颌前庭、上颌前庭、磨牙后三角、腭、颊黏膜、原发性骨内部位）、吸烟和饮酒习惯、浸润深度、神经周围和淋巴管浸润、细胞分化以及术后放疗，以分析危险因素。采用Kaplan-Meier方法估计生存率。采用Cox回归方法在单变量和多变量分析中研究生存的主要独立预测因素。
68例患者在随访期间死于口腔鳞状细胞癌。他们的5年总生存率为51.2%，疾病特异性生存率为59.2%。在单变量分析中，颈部转移、浸润深度、细胞分化、淋巴管浸润、术后放疗、pTNM分期和复发这七个因素与生存显著相关。在多变量分析中，pTNM分期和复发与生存显著相关。
在口腔鳞状细胞癌患者中，pTNM分期和复发是显著的预后因素。颈部转移、浸润深度、细胞分化、淋巴管浸润和术后放疗也是预后因素。这些因素可作为获取口腔鳞状细胞癌预后信息的标志物。
