Oren Burak, Erboga Çaglar, Kocaay Funda, Öztürk Yücel, Bilak Semsettin, Kocabas Dilara Ozkoyuncu, Balli Haci, Bilen Abdurrahman
Ophthalmology, Adiyaman University, Adiyaman, Turkey.
Public Health, Ankara Medipol University, Ankara, Turkey.
Klin Monbl Augenheilkd. 2023 Oct;240(10):1143-1150. doi: 10.1055/a-1990-8942. Epub 2022 Nov 30.
To investigate of the effect of vitamin D (Vit-D) deficiency on the tear film in children and compare it with that of healthy subjects.
This prospective and cross-sectional study comprised 75 eyes of children who had Vit-D deficiency (Group 1) and 85 eyes of age- and gender-matched healthy children (Group 2). The tear-film break-up time (TF-BUT) and Schirmer test values, as well as the Ocular Surface Disease Index (OSDI) scores, were recorded for the participants in all groups. Measurement of the tear meniscus area (TMA) and tear meniscus height (TMH) was performed 2 times in the same day via the use of anterior segment-optical coherence tomography (AS-OCT).
The mean age of the participants in Group 1 was 12.42 ± 3.40 years, while in Group 2, it was 12.59 ± 2.32 years (p = 0.758). Group 1 comprised 43 females and 32 males, while Group 2 comprised 44 females and 41 males (p = 0.250). The mean TMH, TMA, and Schirmer test values were found to be significantly lower in children with Vit-D deficiency (Group 1) than in healthy children (Group 2), with p < 0.05 for all the values. It was concluded that there was no significant difference in the values for the mean TF-BUT and OSDI scores (p = 0.029 and p = 0.596, respectively).
The children with Vit-D deficiency exhibited lower TMH, TMA, and Schirmer test values. The alterations that were observed in these parameters were more prominent in the participants who had lower Vit-D levels.
探讨维生素D（Vit-D）缺乏对儿童泪膜的影响，并与健康受试者进行比较。
这项前瞻性横断面研究包括75例Vit-D缺乏儿童的眼睛（第1组）和85例年龄和性别匹配的健康儿童的眼睛（第2组）。记录所有组参与者的泪膜破裂时间（TF-BUT）、泪液分泌试验值以及眼表疾病指数（OSDI）评分。同一天通过眼前节光学相干断层扫描（AS-OCT）对泪河面积（TMA）和泪河高度（TMH）进行2次测量。
第1组参与者的平均年龄为12.42±3.40岁，第2组为12.59±2.32岁（p = 0.758）。第1组包括43名女性和32名男性，第2组包括44名女性和41名男性（p = 0.250）。发现Vit-D缺乏儿童（第1组）的平均TMH、TMA和泪液分泌试验值显著低于健康儿童（第2组），所有值的p均<0.05。得出结论，平均TF-BUT和OSDI评分的值无显著差异（分别为p = 0.029和p = 0.596）。
Vit-D缺乏的儿童表现出较低的TMH、TMA和泪液分泌试验值。在这些参数中观察到的变化在Vit-D水平较低的参与者中更为明显。
