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免疫功能正常患者的马杜拉诺卡菌性乳突炎和硬膜外脓肿:一种罕见病症

Nocardia Farcinica Mastoiditis and Epidural Abscess in an Immunocompetent Patient: A Rare Entity.

作者信息

Gkrinia Eleni, Bizaki-Vallaskangas Argyro, Rautiainen Markus, Kivekäs Ilkka

机构信息

Department of Ear and Oral Diseases and Otorhinolaryngology, Tampere University, Tampere, Finland.

ENT Department, University Hospital of Larissa and Department of Otorhinolaryngology - Head and Neck Surgery, University of Thessaly, Larissa, Greece.

出版信息

Ear Nose Throat J. 2025 Mar;104(1_suppl):299S-302S. doi: 10.1177/01455613221139400. Epub 2022 Dec 1.

Abstract

Nocardia is regarded as an opportunistic pathogen primarily affecting the respiratory system, whereas is the species of the Nocardia family that is most frequently blamed for central nervous system impairment. The authors present the first case of mastoiditis caused by , accompanied by intracranial complications. An immunocompetent 74-year-old woman who reported a three-week left ear discharge and a two-week facial nerve palsy was referred to our department. MRI revealed mastoiditis and epidural abscess. The bacterial cultures obtained during the surgical management of the patient confirmed the presence of . Targeted antibiotic therapy was subsequently administrated, gradually resulting in favourable outcomes. Nocardia species provoke a disseminated infection that emerges not only among the immunosuppressed individuals but can also affect the healthy population. The nonspecific clinical manifestations in addition to the difficulties identifying the pathogen, remain obstacles to a punctual diagnosis. However, the combination of surgical debridement and antibiotic treatment with trimethoprim and sulfamethoxazole is considered the most appropriate management, leading to propitious results.

摘要

诺卡菌被视为主要影响呼吸系统的机会致病菌,而[具体菌种名称缺失]是诺卡菌属中最常被认为会导致中枢神经系统损害的菌种。作者报告了首例由[具体菌种名称缺失]引起的乳突炎病例,并伴有颅内并发症。一名免疫功能正常的74岁女性,有三周左耳流脓和两周面神经麻痹的症状,被转诊至我科。磁共振成像(MRI)显示为乳突炎和硬膜外脓肿。在对该患者进行手术治疗期间所做的细菌培养证实了[具体菌种名称缺失]的存在。随后进行了针对性的抗生素治疗,逐渐取得了良好的效果。诺卡菌属会引发播散性感染,这种感染不仅会出现在免疫抑制个体中,也可能影响健康人群。除了难以识别病原体外,非特异性的临床表现仍然是及时诊断的障碍。然而,手术清创与使用甲氧苄啶和磺胺甲恶唑进行抗生素治疗相结合被认为是最合适的治疗方法,并能带来良好的效果。

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