Department II of Infectious Diseases, Hangzhou Xixi Hospital, Hangzhou Sixth People's Hospital, Hengbu Street No. 2, Hangzhou, 310023, Zhejiang, China.
BMC Infect Dis. 2024 Oct 3;24(1):1100. doi: 10.1186/s12879-024-10014-x.
Nocardia farcinica is the most pathogenic Nocardia, which is easy to disseminate. It can be caused by trauma, and even lead to severe lung or central nervous system infection. This report covers a case of Nocardia brain abscess in an HIV patient, who underwent resection of the brain abscess, followed by anti-infective therapy with sulfamethoxazole and meropenem, and eventually made a good recovery. The mortality rate of Nocardia farcinica brain abscess has been attributed to the severity of the underlying disease, the difficulty in identifying the pathogen, and its inherent resistance to antibiotics, leading to inappropriate or late initiation of treatment. Medication should follow the principle of sufficient dosage and sufficient course of treatment.
星形奴卡菌是致病性最强的奴卡菌，易播散，可因外伤引起，甚至导致严重的肺部或中枢神经系统感染。本报告涵盖了一例 HIV 患者的奴卡菌脑脓肿病例，该患者接受了脑脓肿切除术，随后接受磺胺甲噁唑和美罗培南抗感染治疗，最终恢复良好。星形奴卡菌脑脓肿的死亡率归因于基础疾病的严重程度、病原体鉴定的困难以及其对抗生素的固有耐药性，导致治疗不当或延迟。用药应遵循足量和足够疗程的原则。
