Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Anatomical Sciences, School of Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Cell Biol Int. 2023 Apr;47(4):683-698. doi: 10.1002/cbin.11970. Epub 2022 Dec 1.
The development of effective treatments for cancers requires investigations for a more detailed and comprehensive understanding of the basic cellular mechanisms involved in carcinogenesis, cancer progression, and metastasis. One of those driving mechanisms is anoikis, a special type of apoptosis, which is induced by losing anchorage from the extracellular matrix (ECM). In other words, resisting death in detached cells (cells without ECM) forms an anoikis-resistant phenotype. Since the anoikis-resistance state compensates for the initial steps of cancer metastasis, this review aimed to discuss mechanisms of gaining anoikis/anoikis resistance phenotype in tumor cells. Finally, we highlighted the significance of anoikis in malignancies so as to provide clear insight into cancer diagnosis and therapy development.
癌症的有效治疗方法的发展需要对参与癌变、癌症进展和转移的基本细胞机制进行更详细和全面的研究。其中一个驱动机制是失巢凋亡，这是一种特殊类型的细胞凋亡，是由细胞从细胞外基质（ECM）上失去附着而引起的。换句话说，在脱离 ECM 的细胞（无 ECM 的细胞）中抵抗死亡会形成失巢凋亡抗性表型。由于失巢凋亡抗性状态弥补了癌症转移的初始步骤，因此本综述旨在讨论肿瘤细胞获得失巢凋亡/失巢凋亡抗性表型的机制。最后，我们强调了失巢凋亡在恶性肿瘤中的重要性，以便为癌症诊断和治疗发展提供清晰的认识。
