Department of Medical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Meta Vision Lab, Samsung Semiconductor Inc., Pasadena, CA, 91101, USA.
Adv Sci (Weinh). 2023 Feb;10(5):e2205113. doi: 10.1002/advs.202205113. Epub 2022 Dec 1.
Augmenting contact lenses with sensing capabilities requires incorporating multiple functionalities within a diminutive device. Inspired by multifunctional biophotonic nanostructures of glasswing butterflies, a nanostructured scleral lens with enhanced optical, bactericidal, and sensing capabilities is reported. When used in conjunction with a smartphone-integrated Raman spectrometer, the feasibility of point-of-care applications is demonstrated. The bioinspired nanostructures made on parylene films are mounted on the anterior and posterior side of a scleral lens to create a nanostructured lens. Compared to unstructured parylene, nanostructured parylene minimizes glare by 4.3-fold at large viewing angles up to 80 . When mounted on a scleral lens, the nanostructures block 2.8-fold more ultraviolet (UVA) light while offering 1.1-fold improved transmission in the visible regime. Furthermore, the nanostructures exhibit potent bactericidal activity against Escherichia coli, killing 89% of tested bacteria within 4 h. The same nanostructures, when gold-coated, are used to perform rapid label-free multiplex detection of lysozyme and lactoferrin, the protein biomarkers of the chronic dry eye disease, in whole human tears using drop-coating deposition Raman spectroscopy. The detection of both proteins in whole human tear samples from different subjects using the nanostructured lens produced excellent correlation with commercial enzyme-based assays while simultaneously displaying a 1.5-fold lower standard deviation.
增强隐形眼镜的感应能力需要在小巧的设备中集成多种功能。受玻璃翅蝶多功能生物光子纳米结构的启发，本文报道了一种具有增强光学、杀菌和感应功能的纳米结构巩膜透镜。当与智能手机集成的拉曼光谱仪结合使用时，证明了即时护理应用的可行性。在聚对二甲苯薄膜上制作的仿生纳米结构被安装在巩膜透镜的前侧和后侧，以形成纳米结构透镜。与非纳米结构的聚对二甲苯相比，纳米结构的聚对二甲苯在大视角（高达 80 度）下将眩光最小化了 4.3 倍。当安装在巩膜透镜上时，纳米结构阻挡了 2.8 倍的紫外线（UVA）光，同时在可见光范围内提高了 1.1 倍的透过率。此外，纳米结构对大肠杆菌具有强大的杀菌活性，在 4 小时内杀死了 89%的测试细菌。同样的纳米结构，在镀金后，用于通过滴涂沉积拉曼光谱法在全人泪液中快速进行无标记多重检测溶菌酶和乳铁蛋白，这两种蛋白质是慢性干眼症的生物标志物。使用纳米结构透镜在来自不同个体的全人泪样中检测到这两种蛋白质，与商业基于酶的检测方法具有极好的相关性，同时显示出低 1.5 倍的标准偏差。
