Yamamoto Kenzo, Hara Kazuaki, Kobayashi Etsuko, Akagi Yuki, Sakuma Ichiro
Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Int J Comput Assist Radiol Surg. 2023 Mar;18(3):587-594. doi: 10.1007/s11548-022-02794-x. Epub 2022 Dec 1.
Post-surgical complications are correlated to the surgeon's technical skill level. Thus, efforts are being put in finding ways to improve the surgeon's technical skills, such as not causing unwanted damage to tissues during surgery. In this study, we aim to investigate the possibility of estimating biological tissue damage, in view of preventing unwanted damage during surgery.
A series of tensile tests were performed on porcine small intestinal tissue to determine the elasticity and the tearing force. The tissue was then microscopically observed to investigate the influence of fibrous protein configuration in the tissue's mechanical properties.
The results from the tensile test showed that the fracture energy had a positive and linear correlation with the elasticity to the negative 0.5th power (R = 0.897), which was also suggested by an existing damage model for polymeric materials (Lake-Thomas model). The results from the microscopic observations also showed a resembling influence of fiber configuration on the elasticity as suggested in polymer mechanics (affine network model).
We showed that the fracture energy had a correlation with the elasticity in porcine small intestinal tissues, which was also suggested in polymer mechanics, thus being a promising avenue toward the ability to estimate the maximum applicable force onto a biological tissue without causing damage during surgery. Attention should also be pointed, however, towards investigating the extent at which polymer mechanics and biomechanics overlap.
术后并发症与外科医生的技术水平相关。因此，人们正在努力寻找提高外科医生技术水平的方法，比如在手术过程中不对外科组织造成不必要的损伤。在本研究中，我们旨在探讨估计生物组织损伤的可能性，以期在手术过程中防止不必要的损伤。
对猪小肠组织进行了一系列拉伸试验，以确定其弹性和撕裂力。然后对该组织进行显微镜观察，以研究纤维蛋白结构对组织力学性能的影响。
拉伸试验结果表明，断裂能与弹性的负0.5次幂呈正线性相关（R = 0.897），这也被现有的聚合物材料损伤模型（Lake-Thomas模型）所证实。显微镜观察结果还表明，纤维结构对弹性的影响与聚合物力学（仿射网络模型）中所提出的相似。
我们表明，断裂能与猪小肠组织的弹性相关，这在聚合物力学中也有提及，因此有望实现估计作用于生物组织上的最大适用力而在手术过程中不造成损伤的能力。然而，还应关注研究聚合物力学与生物力学重叠的程度。
