Arrhythmia Unit, San Raffaele University Hospital, Milan, Italy.
ESC Working Group on Cardiac Cellular Electrophysiology, Sophia Antipolis, Cannes, France.
Adv Exp Med Biol. 2023;1396:129-137. doi: 10.1007/978-981-19-5642-3_9.
Atrial fibrillation (AF) is a frequent rhythm disturbance that raises the possibility of heart failure (HF) and stroke. AF is a multifactorial disorder combining genetic and environmental etiologies. Over the last decade, advancements have been made regarding the genetic base of this arrhythmia. We present the existing knowledge of genetic analysis and genome editing for atrial fibrillation, indicating the existing gaps and future directions. We aim to elucidate how genome editing could be utilized for patients with atrial fibrillation.
心房颤动（AF）是一种常见的节律紊乱，增加了心力衰竭（HF）和中风的可能性。AF 是一种多因素疾病，结合了遗传和环境病因。在过去的十年中，关于这种心律失常的遗传基础已经取得了进展。我们介绍了用于心房颤动的遗传分析和基因组编辑的现有知识，指出了现有差距和未来方向。我们旨在阐明基因组编辑如何用于心房颤动患者。
