National Medicines Institute, 30/34 Chełmska Street, 00-725, Warsaw, Poland.
Forensic Toxicol. 2022 Jan;40(1):132-143. doi: 10.1007/s11419-021-00597-4. Epub 2021 Sep 14.
New psychoactive substances (NPSs) still appear on the market, mainly due to their legal status. This situation indicates and alarms that permanent recognition of the designer drug scene should be conducted. In this paper, we describe the detection of three psychoactive substances in samples collected from drug users.
Qualitative characterization was performed using liquid chromatography-high-resolution tandem mass spectrometry with a quadrupole time-of-flight analyzer, gas chromatography with mass spectrometry and nuclear magnetic resonance spectroscopy.
In this study, we reported the detection and structural elucidation of three psychoactive substances: 1-(4-bromophenyl)piperazine (pBPP), 1-(3-chloro-4-fluorophenyl)piperazine (3,4-CFPP) and methyl 8-methyl-3-phenyl-8-azabicyclo[3.2.1]octane-4-carboxylate (troparil).
To the best of our knowledge, this is the first report that presents an identification methodology for these substances found in illegal products. Comprehensive characterization of the NPSs presented in this paper facilitates their detection and identification by forensic and clinical laboratories.
新精神活性物质（NPS）仍不断出现在市场上，主要是因为它们的法律地位。这种情况表明并警示我们，应持续关注设计药物领域。本文描述了从吸毒者采集的样本中检测到的三种精神活性物质。
使用带有四极杆飞行时间分析仪的液相色谱-高分辨串联质谱法、气相色谱-质谱法和核磁共振波谱法进行定性特征描述。
在本研究中，我们报道了三种精神活性物质的检测和结构阐明：1-(4-溴苯基)哌嗪（pBPP）、1-(3-氯-4-氟苯基)哌嗪（3,4-CFPP）和 8-甲基-3-苯基-8-氮杂双环[3.2.1]辛烷-4-羧酸甲酯（曲罗匹隆）。
据我们所知，这是首次报道在非法产品中发现这些物质的鉴定方法。本文对 NPS 的全面特征描述有助于法医和临床实验室对其进行检测和识别。
