前列环素（PGI2）在体内的抗聚集作用。
Anti-aggregatory effect of prostacyclin (PGI2) in vivo.
作者信息
Bayer B L, Blass K E, Förster W
出版信息
Br J Pharmacol. 1979 May;66(1):10-2. doi: 10.1111/j.1476-5381.1979.tb16090.x.
Abstract
Prostacyclin (PGI2) when infused intravenously reduced the mortality of rabbits given high intravenous doses of arachidonic acid (AA). Prostaglandins E1 and D2 were ineffective. Indomethacin pretreatment abolished the toxic AA effect. Since the lethal effect of AA is partly due to the formation of platelet aggregates it is concluded that PGI2 is a most potent anti-aggregatory prostaglandin in vivo.
摘要
静脉注射前列环素（PGI2）可降低静脉注射大剂量花生四烯酸（AA）的家兔死亡率。前列腺素E1和D2无效。吲哚美辛预处理可消除AA的毒性作用。由于AA的致死作用部分归因于血小板聚集的形成，因此得出结论：PGI2是体内一种最有效的抗聚集前列腺素。
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本文引用的文献
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Br Med J. 1967 May 20;2(5550):468-72. doi: 10.1136/bmj.2.5550.468.
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Arachidonic acid causes sudden death in rabbits.花生四烯酸可导致兔子猝死。
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The effect of prostaglandin E1 on platelet function in vitro and in vivo.前列腺素E1对体内外血小板功能的影响。
Br J Haematol. 1970 Nov;19(5):559-71. doi: 10.1111/j.1365-2141.1970.tb01639.x.
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Intravenous arachidonate in the mouse: a model for the evaluation of antithrombotic drugs.小鼠静脉注射花生四烯酸盐：一种评估抗血栓药物的模型。
Thromb Res. 1976 Jul;9(1):67-80. doi: 10.1016/0049-3848(76)90150-x.
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