Yeung Jennifer, Hawley Megan, Holinstat Michael
Department of Pharmacology, University of Michigan, 1150 W. Medical Center Dr., Room 2220D, Ann Arbor, MI, 48109-5632, USA.
Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
J Mol Med (Berl). 2017 Jun;95(6):575-588. doi: 10.1007/s00109-017-1542-4. Epub 2017 May 20.
In mammals, three major oxygenases, cyclooxygenases (COXs), lipoxygenases (LOXs), and cytochrome P450 (CYP450), generate an assortment of unique lipid mediators (oxylipins) from polyunsaturated fatty acids (PUFAs) which exhibit pro- or anti-thrombotic activity. Over the years, novel oxylipins generated from the interplay of theoxygenase activity in various cells, such as the specialized pro-resolving mediators (SPMs), have been identified and investigated in inflammatory disease models. Although platelets have been implicated in inflammation, the role and mechanism of these SPMs produced from immune cells on platelet function are still unclear. This review highlights the burgeoning classes of oxylipins that have been found to regulate platelet function; however, their mechanism of action still remains to be elucidated.
在哺乳动物中，三种主要的加氧酶，即环氧化酶（COXs）、脂氧合酶（LOXs）和细胞色素P450（CYP450），可从多不饱和脂肪酸（PUFAs）生成一系列具有促血栓或抗血栓活性的独特脂质介质（氧化脂质）。多年来，在炎症疾病模型中，已鉴定并研究了由各种细胞（如特殊促消退介质（SPMs））中的加氧酶活性相互作用产生的新型氧化脂质。尽管血小板与炎症有关，但免疫细胞产生的这些SPMs对血小板功能的作用和机制仍不清楚。本综述重点介绍了已发现可调节血小板功能的新兴氧化脂质类别；然而，它们的作用机制仍有待阐明。
