铑催化的形式C═O键插入及连续酰基1,4-氮到氧的迁移重排
Rhodium-Catalyzed Formal C═O Bond Insertion and Sequential Acyl 1,4-N-to-O Migratory Rearrangement.
作者信息
Li Qiongya, He Chunlan, Su Jiahui, Shao Ying, Tang Shengbiao, Sun Jiangtao
机构信息
Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China.
出版信息
J Org Chem. 2022 Dec 16;87(24):16937-16940. doi: 10.1021/acs.joc.2c02328. Epub 2022 Dec 1.
PMID:36455299
Abstract
We present here a rhodium-catalyzed reaction between -acyl pyridazinones and diazoacetates, leading to pyridazine derivatives in good yield under mild reaction conditions. This whole sequence probably proceeds through a carbene insertion into a C═O bond and an unprecedented 1,4- acyl rearrangement reaction.
摘要
我们在此展示了一种铑催化的α-酰基哒嗪酮与重氮乙酸酯之间的反应，该反应在温和的反应条件下能以良好的产率生成哒嗪衍生物。整个反应过程可能是通过卡宾插入C═O键以及一个前所未有的1,4-酰基重排反应来进行的。
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