铑催化的 2-吡啶酮的 -芳基化反应，通过 2-氧代吡啶的 1,6-酰基迁移重排实现。
Rhodium-Catalyzed -Arylation of 2-Pyridones Enabled by 1,6-Acyl Migratory Rearrangement of 2-Oxypyridines.
机构信息
Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China.
出版信息
Org Lett. 2023 Mar 24;25(11):1974-1977. doi: 10.1021/acs.orglett.3c00519. Epub 2023 Mar 15.
PMID:36920185
Abstract
An efficient rhodium-catalyzed dearomative rearrangement of 2-oxypyridines with quinone diazides has been developed for the direct synthesis of -arylated pyridones, in which a novel 1,6--to- rather than 1,4--to- acyl rearrangement has been achieved under mild reaction conditions.
摘要
发展了一种高效的铑催化 2-氧代吡啶与重氮二羧酸酯的去芳构化重排反应，用于直接合成芳基化的吡啶酮，在温和的反应条件下，实现了新颖的 1,6- 而非 1,4-酰基重排。
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