Gao Ning, Deng Jiang, Wang Jinhai, Zhou Zhihua, Yao Cong, Zhou Mimi, Xing Xin, Wang Qian, Lu Xiaolan, Shi Haitao
Department of Infectious Disease, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Front Med (Lausanne). 2022 Nov 15;9:1038475. doi: 10.3389/fmed.2022.1038475. eCollection 2022.
To analyze the prevalence, associated comorbidities, influencing factors, and identifying factors of non-obese fatty liver disease and to provide a reference for its prevention and treatment.
Firstly, to screen data obtained from the physical examinations of individuals conducted in the Second Affiliated Hospital of Xi'an Jiaotong University in 2021, subjects with complete data of abdominal ultrasonography, body mass index, age and sex were selected to analyze the prevalence of fatty liver disease and non-obese fatty liver disease. Secondly, to screen non-obese subjects who had data for triglycerides, fasting blood glucose, and so on, to analyze the complications, influencing factors, and identifying factors of non-obese fatty liver disease.
The prevalence of fatty liver disease was 27.8% (18,416/66,221), including 33.9% (11,921/35,131) in males and 20.9% (6,495/31,090) in females, revealing that the prevalence was significantly higher in males than in females ( < 0.001). There were 40,673 non-obese subjects screened in total, and the prevalence of non-obese fatty liver disease was 13.0% (5,307/40,673). The prevalence of non-obese fatty liver disease was 13.3% (2,208/16,572) in males and 12.9% (3,099/24,101) in females; the difference was not statistically significant ( = 0.17). The serum triglycerides level was elevated in 54.2% of subjects with non-obese fatty liver disease, and this was the most common abnormal metabolic index accompanying the disease. Logistic regression analysis showed that gender, age, body mass index, blood pressure, alanine aminotransferase, aspartate aminotransferase, fasting blood glucose, triglycerides, total cholesterol, and serum uric acid were independent risk factors for non-obese fatty liver disease ( < 0.001). For triglycerides, the area under the receiver operating characteristic curve in predicting non-obese fatty liver disease was the greatest (0.806).
The prevalence of fatty liver disease and non-obese fatty liver disease determined by the physical examination of individuals was high, and the triglycerides is likely to be useful for the extensive screening of non-obese fatty liver disease.
分析非肥胖型脂肪肝的患病率、合并症、影响因素及识别因素，为其防治提供参考。
首先，筛选西安交通大学第二附属医院2021年个体体检获得的数据，选取腹部超声、体重指数、年龄和性别数据完整的受试者，分析脂肪肝和非肥胖型脂肪肝的患病率。其次，筛选有甘油三酯、空腹血糖等数据的非肥胖受试者，分析非肥胖型脂肪肝的并发症、影响因素及识别因素。
脂肪肝患病率为27.8%（18416/66221），其中男性为33.9%（11921/35131），女性为20.9%（6495/31090），男性患病率显著高于女性（<0.001）。共筛选出40673名非肥胖受试者，非肥胖型脂肪肝患病率为13.0%（5307/40673）。男性非肥胖型脂肪肝患病率为13.3%（2208/16572），女性为12.9%（3099/24101）；差异无统计学意义（=0.17）。54.2%的非肥胖型脂肪肝受试者血清甘油三酯水平升高，这是该疾病最常见的异常代谢指标。Logistic回归分析显示，性别、年龄、体重指数、血压、谷丙转氨酶、谷草转氨酶、空腹血糖、甘油三酯、总胆固醇和血清尿酸是非肥胖型脂肪肝的独立危险因素（<0.001）。对于甘油三酯，其预测非肥胖型脂肪肝的受试者工作特征曲线下面积最大（0.806）。
通过个体体检确定的脂肪肝和非肥胖型脂肪肝患病率较高，甘油三酯可能有助于非肥胖型脂肪肝的广泛筛查。
