Xu Qiying, Liu Huifang, Qile Muge, Wuren Tana
Department of Gynecology, Affiliated Hospital of Qinghai University, Xining, China.
Key Laboratory for Application of High-Altitude Medicine, Qinghai University, Xining, China.
Front Med (Lausanne). 2022 Nov 15;9:940554. doi: 10.3389/fmed.2022.940554. eCollection 2022.
Various studies have described the roles of myeloid-derived suppressor cells (MDSCs) in pathological conditions, but relatively few have described them under normal physiological conditions. Accumulation of MDSCs is important creating an anti-inflammation environment, which is essential for fertilized egg implantation. This study was designed to record the dynamic changes in MDSC-like cells composition during the menstrual period (MP) and ovulation period (OP) in healthy volunteers over the course of a single menstrual cycle to explore the association between MDSCs and the menstrual cycle under normal physiological conditions. The ratio of MDSC-like cells was higher in MP samples, whereas the activity of Arg-1 was higher during the OP window. There was a negative correlation between the ratio of MDSC-like cells and the percentage of lymphocytes and a positive correlation between MDSC-like cells and prostaglandin E2 (PGE2). Furthermore, regular changes in the ratio and function of MDSC-like cells in the peripheral blood were observed during menstruation, all of which corresponded to the cycle stage. During menstruation, MDSCs may promote endometrial repair, whereas they promote pregnancy during the OP. These findings may help to better understand the pathophysiology of pregnancy-related complications and lay a foundation for improving perinatal outcomes.
多项研究描述了髓系来源的抑制细胞（MDSCs）在病理状态下的作用，但相对较少有研究描述它们在正常生理条件下的情况。MDSCs的积累对于营造抗炎环境很重要，而抗炎环境对受精卵着床至关重要。本研究旨在记录健康志愿者在单个月经周期过程中月经期（MP）和排卵期（OP）期间MDSC样细胞组成的动态变化，以探讨正常生理条件下MDSCs与月经周期之间的关联。MP样本中MDSC样细胞的比例较高，而在OP窗口期精氨酸酶-1（Arg-1）的活性较高。MDSC样细胞的比例与淋巴细胞百分比之间呈负相关，MDSC样细胞与前列腺素E2（PGE2）之间呈正相关。此外，在月经期间观察到外周血中MDSC样细胞的比例和功能有规律的变化，所有这些都与周期阶段相对应。在月经期间，MDSCs可能促进子宫内膜修复，而在OP期间它们促进妊娠。这些发现可能有助于更好地理解与妊娠相关并发症的病理生理学，并为改善围产期结局奠定基础。
