Biswas Hiranmoy, Roy Babul Chandra, Hasan Mohammad Manjurul, Ahmed Nurnabi, Dutta Pallab Kumar, Begum Nurjahan, Talukder Md Hasanuzzaman
Department of Parasitology, Bangladesh Agricultural University, Mymensingh, 2202 Bangladesh.
Department of Livestock Services, Krishi Khamar Sarak, Dhaka, 1215 Bangladesh.
J Parasit Dis. 2022 Dec;46(4):988-997. doi: 10.1007/s12639-022-01522-1. Epub 2022 Jul 19.
Toxocariasis is a paramount parasitic disease having > 50% prevalence among newborn buffalo calves in Bangladesh. The objective of this study was to compare the efficacy of clinically used anthelmintics and their subsequent effect on the haematological parameters and body weight in buffalo calves in commercial buffalo farms in coastal region. Thirty-two buffalo calves below 3 months of age with clinical infection had been selected and treated with albendazole (ABZ), levamisole (LVM) and ivermectin (IVM). The EPG counts, hematological parameters and initial body weight of buffalo calves were recorded on the day of anthelmintic treatment (day 0). Fecal samples were collected on day 14 and 28 including hematological parameters and body weight were recorded on day 28 post-treatment. The efficacy (%) of anthelmintics were estimated by fecal egg count reduction test (FECRT). The parameters like Hb, PCV, ESR, TEC, TLC were analyzed from the blood samples. The FECRT revealed 96.83% efficacy for IVM followed by 94.23% and 85.84% for LVM and ABZ, respectively. Anthelmintic treated calves showed significant ( < 0.01) increase in Hb, PCV, TEC and body weight, and decrease in ESR and TLC as a result of worm expulsion from buffalo calves after 28 days of post-treatment. Among the tested anthelmintics, IVM was found to be more effective against toxocariasis in buffalo calves. This is a novel information on anthelmintics efficacy in buffalo calves in Bangladesh. Details study is recommended on the efficacy of anthelmintics in different buffalo management systems by in vitro egg hatch assay (EHA) test.
弓首蛔虫病是一种主要的寄生虫病，在孟加拉国新生水牛犊中的患病率超过50%。本研究的目的是比较临床使用的驱虫药的疗效及其对沿海地区商业水牛养殖场水牛犊血液学参数和体重的后续影响。选择了32头3月龄以下有临床感染的水牛犊，并用阿苯达唑（ABZ）、左旋咪唑（LVM）和伊维菌素（IVM）进行治疗。在驱虫治疗当天（第0天）记录水牛犊的每克粪便虫卵数（EPG）、血液学参数和初始体重。在第14天和第28天采集粪便样本，在治疗后第28天记录血液学参数和体重。通过粪便虫卵计数减少试验（FECRT）评估驱虫药的疗效（%）。从血样中分析血红蛋白（Hb）、红细胞压积（PCV）、红细胞沉降率（ESR）、红细胞计数（TEC）、白细胞计数（TLC）等参数。FECRT显示，IVM的疗效为96.83%，其次是LVM的94.23%和ABZ的85.84%。驱虫治疗后的犊牛在治疗后28天因水牛犊体内蠕虫排出，Hb、PCV、TEC和体重显著增加（<0.01），ESR和TLC降低。在测试的驱虫药中，发现IVM对水牛犊的弓首蛔虫病更有效。这是关于孟加拉国水牛犊驱虫药疗效的新信息。建议通过体外虫卵孵化试验（EHA）对不同水牛管理系统中驱虫药的疗效进行详细研究。
