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A retrograde approach for liver gene transfer.

作者信息

Brunetti-Pierri Nicola, Gissen Paul

机构信息

Telethon Institute of Genetics and Medicine, Pozzuoli, Italy.

Department of Translational Medicine, Federico II University, Naples, Italy.

出版信息

Mol Ther Methods Clin Dev. 2022 Nov 25;27:488-490. doi: 10.1016/j.omtm.2022.11.002. eCollection 2022 Dec 8.

DOI:10.1016/j.omtm.2022.11.002
PMID:36458113
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9709090/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/410d/9709090/65f006721bb9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/410d/9709090/65f006721bb9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/410d/9709090/65f006721bb9/gr1.jpg

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本文引用的文献

1
Intrabiliary infusion of naked DNA vectors targets periportal hepatocytes in mice.裸DNA载体经胆管内输注可靶向小鼠的门静脉周围肝细胞。
Mol Ther Methods Clin Dev. 2022 Oct 10;27:352-367. doi: 10.1016/j.omtm.2022.10.006. eCollection 2022 Dec 8.
2
Delivery of non-viral naked DNA vectors to liver in small weaned pigs by hydrodynamic retrograde intrabiliary injection.通过流体动力学逆行胆管内注射将非病毒裸DNA载体递送至断奶仔猪肝脏。
Mol Ther Methods Clin Dev. 2022 Jan 19;24:268-279. doi: 10.1016/j.omtm.2022.01.006. eCollection 2022 Mar 10.
3
Single amino acid insertion allows functional transduction of murine hepatocytes with human liver tropic AAV capsids.
单氨基酸插入可实现人肝脏嗜性腺相关病毒衣壳对小鼠肝细胞的功能性转导。
Mol Ther Methods Clin Dev. 2021 Apr 24;21:607-620. doi: 10.1016/j.omtm.2021.04.010. eCollection 2021 Jun 11.
4
Single-cell spatial reconstruction reveals global division of labour in the mammalian liver.单细胞空间重建揭示了哺乳动物肝脏中的全局分工。
Nature. 2017 Feb 16;542(7641):352-356. doi: 10.1038/nature21065. Epub 2017 Feb 6.
5
Inverse zonation of hepatocyte transduction with AAV vectors between mice and non-human primates.利用 AAV 载体在小鼠和非人灵长类动物之间进行肝细胞转导的反向分区。
Mol Genet Metab. 2011 Nov;104(3):395-403. doi: 10.1016/j.ymgme.2011.06.002. Epub 2011 Jun 12.
6
Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA.通过全身给药质粒DNA在动物中基于流体动力学的转染
Gene Ther. 1999 Jul;6(7):1258-66. doi: 10.1038/sj.gt.3300947.
7
High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA.尾静脉注射裸质粒DNA后肝细胞中外源基因的高表达水平。
Hum Gene Ther. 1999 Jul 1;10(10):1735-7. doi: 10.1089/10430349950017734.
8
Expression of naked plasmid DNA injected into the afferent and efferent vessels of rodent and dog livers.注射到啮齿动物和狗肝脏的传入和传出血管中的裸质粒DNA的表达。
Hum Gene Ther. 1997 Oct 10;8(15):1763-72. doi: 10.1089/hum.1997.8.15-1763.
9
Naked DNA delivered intraportally expresses efficiently in hepatocytes.经门静脉注射的裸DNA在肝细胞中高效表达。
Gene Ther. 1996 Jul;3(7):593-8.