Li Xi, Luo Bo, Liao Min, Mohamed Abdullah
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Department of Traditional Chinese Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Front Chem. 2022 Nov 11;10:997662. doi: 10.3389/fchem.2022.997662. eCollection 2022.
Fentanyl was successfully determined in the current effort based on hexagonal NiO nanodisks (HG-NiO-NDs) fabricated by the hydrothermal protocol. The synergism of HG-NiO-NDs with multiwall carbon nanotubes (MWCNTs), large specific surface area, and active material enabled the electrochemical sensor to show potent electrochemical behavior. Admirable performance was found for the fentanyl measurement by the MWCNT and HG-NiO-ND-modified pencil graphite electrode (MWCNT/HG-NiO-ND/PGE). The correlation of oxidation currents with the pH value, concentration, and sweep rate of supporting electrolytes was determined for the optimization of conditions to detect fentanyl. The surfaces of modified and unmodified electrodes were characterized as well. The diffusion-control processes were confirmed on the basis of anodic peak findings. The results also revealed a two-electron transfer process. The linear range was obtained to be 0.01-800.0 μM for the fentanyl concentrations on the developed electrode, with the sensitivity of 0.1044 μA/mM/cm. The limit of detection (S/N = 3) was 6.7 nM. The results indicated the ability of the modified electrode to fabricate non-enzymatic fentanyl sensor applications.
基于水热法制备的六方氧化镍纳米盘（HG-NiO-NDs），在当前的研究中成功测定了芬太尼。HG-NiO-NDs与多壁碳纳米管（MWCNTs）的协同作用、大比表面积和活性材料使电化学传感器表现出强大的电化学行为。通过MWCNT和HG-NiO-ND修饰的铅笔石墨电极（MWCNT/HG-NiO-ND/PGE）对芬太尼进行测量时发现了令人满意的性能。确定了氧化电流与支持电解质的pH值、浓度和扫描速率之间的相关性，以优化检测芬太尼的条件。还对修饰电极和未修饰电极的表面进行了表征。根据阳极峰的发现证实了扩散控制过程。结果还揭示了双电子转移过程。所开发电极上芬太尼浓度的线性范围为0.01 - 800.0 μM，灵敏度为0.1044 μA/mM/cm。检测限（S/N = 3）为6.7 nM。结果表明修饰电极能够用于制造非酶芬太尼传感器应用。
